Results 51 to 60 of about 8,611 (241)

Persistent homological cell tracking technology

Scientific Reports, 2023
AbstractIn this paper, we develop a cell tracking method based on persistent homological figure detection technology. We apply our tracking method to 9 different time-series cell images and extract several kinds of cell movements. Being able to analyze various images with a single method allows researchers to systematically understand and compare ...
Haruhisa Oda, Kazuo Tonami, Yoichi Nakata, Naoko Takubo, Hiroki Kurihara   +4 more
openaire   +3 more sources

The (p)ppGpp synthetase Rsh promotes rifampicin tolerant persister cell formation in Brucella abortus by regulating the type II toxin-antitoxin module mbcTA

Frontiers in Microbiology
Persister cells are transiently tolerant to antibiotics and are associated with recalcitrant chronic infections due to recolonization of host cells after antibiotic removal. Brucella spp.
Xiaofang Liu, Xiaofang Liu, Pingping Wang, Pingping Wang, Ningqiu Yuan, Ningqiu Yuan, Yunyi Zhai, Yunyi Zhai, Yuanhao Yang, Yuanhao Yang, Mingyue Hao, Mingyue Hao, Mingxing Zhang, Mingxing Zhang, Dong Zhou, Dong Zhou, Wei Liu, Wei Liu, Yaping Jin, Yaping Jin, Aihua Wang, Aihua Wang   +21 more
doaj   +1 more source

Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells

mBio, 2017
There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and ...
Jun-Seob Kim, Thomas K. Wood
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Persister cells in a biofilm treated with a biocide [PDF]

Biofouling, 2011
This study investigated the physiology and behaviour following treatment with ortho-phthalaldehyde (OPA), of Pseudomonas fluorescens in both the planktonic and sessile states. Steady-state biofilms and planktonic cells were collected from a bioreactor and their extracellular polymeric substances (EPS) were extracted using a method that did not destroy ...
Simões, Lúcia C., Lemos, Madalena, Pereira, Ana M., Abreu, Ana C., Saavedra, Maria J., Simões, M.   +5 more
openaire   +3 more sources

Fungal persister cells: The basis for recalcitrant infections? [PDF]

PLoS Pathogens, 2018
Persister cells are a small subpopulation within fungal biofilms that are highly resistant to high concentrations of antifungals and therefore most likely contribute to the resistance and recalcitrance of biofilm infections.
Jurgen Wuyts, Patrick Van Dijck, Michelle Holtappels   +2 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Persisting cancer cells are different from bacterial persisters

Trends in Cancer
The persistence of drug-sensitive tumors poses a significant challenge in cancer treatment. The concept of bacterial persisters, which are a subpopulation of bacteria that survive lethal antibiotic doses, is frequently used to compare to residual disease in cancer. Here, we explore drug tolerance of cancer cells and bacteria. We highlight the fact that
Decollogny, Morgane, Rottenberg, Sven
openaire   +2 more sources

Alloreactive T cells and ‘the persistence of memory’ [PDF]

Kidney International, 2013
Circulating donor-reactive effector memory T cells have been associated with allograft injury in humans. The next step to translate this observation into clinical practice is the design of clinical trials aimed at individualization of T cell-targeted therapy.
Emilio D, Poggio, Joshua J, Augustine
openaire   +2 more sources

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source