Results 71 to 80 of about 8,611 (241)

T cell response and persistence of the microsporidia [PDF]

FEMS Microbiology Reviews, 2012
The microsporidia are a diverse phylum of obligate intracellular parasites related to the fungi that cause significant and sometimes life-threatening disease in immune-compromised hosts, such as AIDS and organ transplant patients. More recently, their role in causing pathology in immune-competent populations has also been appreciated. Interestingly, in
Kaya, Ghosh, Louis M, Weiss
openaire   +2 more sources

Ribosome State Distributions Define Escherichia coli Persister Physiology: Links to Formation, Stress Responses, and Resuscitation Dynamics

Microbial Biotechnology
Persister cells survive antibiotic exposure and contribute to infection relapse, yet the molecular features that distinguish them from actively growing cells remain incompletely defined.
Hyein Kim, Sooyeon Song
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Mcl-1 and tumor cell persistence

Oncotarget, 2014
Effective genotoxic cancer therapies induce not only classical apoptotic cell death, but also senescence, a persistent state of cell cycle arrest accompanied by distinct morphological and biochemical changes. A number of studies in both animal and human models demonstrate that senescence plays a key role in limiting tumor growth and correlate with ...
Lukas W, Pfannenstiel, Brian R, Gastman
openaire   +2 more sources

Gene Panel of Persister Cells as a Prognostic Indicator for Tumor Repopulation After Radiation

Frontiers in Oncology, 2020
Tumor repopulation during cycles of radiotherapy limits the radio-response in ensuing cycles and causes failure of treatment. It is thus of vital importance to unveil the mechanisms underlying tumor repopulating cells. Increasing evidence suggests that a
Yucui Zhao, Yanwei Song, Ruyi Zhao, Minghui Zhao, Qian Huang   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Ampicillin treatment in persister cell studies may cause non-physiological artifacts

Microbial Cell
Persister cells are a clinically relevant sub-population of an isogenic bacterial culture that is tolerant to bactericidal antibiotics. With the aim to investigate the ribosomal protein content of persister cells, we employed the bacteriolytic properties
Michel Fasnacht, Hena Comic, Isabella Moll   +2 more
doaj   +1 more source

ATP-Dependent Persister Formation in Escherichia coli

mBio, 2017
Persisters are dormant variants that form a subpopulation of cells tolerant to antibiotics. Persisters are largely responsible for the recalcitrance of chronic infections to therapy.
Yue Shan, Autumn Brown Gandt, Sarah E. Rowe, Julia P. Deisinger, Brian P. Conlon, Kim Lewis   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Quorum Sensing-Regulated Phenol-Soluble Modulins Limit Persister Cell Populations in Staphylococcus aureus

Frontiers in Microbiology, 2018
Incomplete killing of bacterial pathogens by antibiotics is an underlying cause of treatment failure and accompanying complications. Among those avoiding chemotherapy are persisters being individual cells in a population that for extended periods of time
Martin S. Bojer, Martin S. Bojer, Søren Lindemose, Martin Vestergaard, Hanne Ingmer, Hanne Ingmer   +5 more
doaj   +1 more source