Results 61 to 70 of about 613,460 (341)
Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack +12 more
wiley +1 more source
Translational and Personalized Medicine
Medicine, Law & Society, 2015 The idea behind personalized medicine is to tailor health care to an individual’s unique genetic makeup. Hitherto, “one size fits all” approach was used in medicine. With the rise of personal medicine, we are moving towards a more precise, predictable and powerful medicine that is customized for each individual patient.
Kraljević-Pavelić, Sandra +2 more
openaire +4 more sources
Is the way we're dieting wrong? [PDF]
, 2016 Progress in personalized medicine is now being translated to personalized nutrition. A recent proof-of-concept study shows that the increase in blood glucose levels after a meal is highly variable between individuals, but can be predicted by using a ...
Dumas, M-E
core +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine [PDF]
, 2023 Lenka Koklesová +12 more
openalex +1 more source
PERSONALIZED PHARMACOTHERAPY IN PSYCHIATRY [PDF]
, 2009 The hypothesis of each individual being special and different leading to heterogenity of diseases sets the ground for the concept of personalized medicine. Personalized psychiatry follows the principles of personalized medicine.
Anamarija Petek, Pavo Filaković
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Personalized Education: Analog of Personalized Medicine? [PDF]
Psychology and Behavioral Science International Journal, 2017 This chapter discusses the role of genetically influenced normal-range intelligence in educational achievement and attainment. I suggest that there is evidence that we have developed an educational system that reinforces genetic disadvantage contributing to low educational achievement and genetic advantage contributing to high educational achievement ...
openaire +2 more sources
Integration-free reprogramming of lamina propria progenitor cells [PDF]
, 2016 Producing induced pluripotent stem cells (iPSCs) from human tissue for use in personalized medicine strategies or therapeutic testing is at the forefront of medicine.
Allen, Nicholas Denby +4 more
core +1 more source