Results 71 to 80 of about 576,044 (343)

Genetic basis for personalized medicine in asthma [PDF]

, 2012
There is heterogeneity in patient responses to current asthma medications. Significant progress has been made identifying genetic polymorphisms that influence the efficacy and potential for adverse effects to asthma drugs, including; β2-adrenergic ...
Asano, Barnes, Basu, Bleecker, Bleecker, Choudhry, Corren, Currie, Drazen, Drysdale, Duan, Duroudier, Ferreira, Finotto, Gaston, Gudbjartsson, Haldar, Hall, Hammad, Hawkins, Hawkins, Hayakawa, Himes, Holloway, Ian Sayers, Israel, Jin, Kang, Kearley, Kim, Klotsman, Koster, Lee, Lee, Lima, Lima, Litonjua, Liu, Maarsingh, Malmstrom, Mastalerz, Meurs, Michael Portelli, Moffatt, Moffatt, Moore, Mougey, Obeidat, Ober, Oshikawa, Panebra, Panebra, Pascual, Prefontaine, Reihsaus, Risma, Sampson, Savenije, Sayers, Sayers, Slager, Sleiman, Stevens, Tantisira, Tantisira, Tantisira, Tantisira, Torgerson, Trian, Tse, Vonk, Wechsler, Wenzel, Whalen, Whelan, Ye, York   +76 more
core   +2 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Moving Towards Personalized Medicine

Siriraj Medical Journal, 2020
-
Naravat Poungvarin
doaj  

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Nominalism in Medicine: the case of personalized medicine or precision medicine

Italian Journal of Medicine, 2017
Not ...
Italo Portioli
doaj   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

PERSONALIZED PHARMACOTHERAPY IN PSYCHIATRY [PDF]

, 2009
The hypothesis of each individual being special and different leading to heterogenity of diseases sets the ground for the concept of personalized medicine. Personalized psychiatry follows the principles of personalized medicine.
Anamarija Petek, Pavo Filaković
core   +1 more source

Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training. [PDF]

, 2018
Predicting treatment outcomes in psychiatric populations remains a challenge, but is increasingly important in the pursuit of personalized medicine. Patients with schizophrenia have deficits in cognition, and targeted cognitive training (TCT) of auditory
Carter, Cameron S, Fisher, Melissa, Loewy, Rachel L, Ma, Sisi, Niendam, Tara, Ragland, J Daniel, Ramsay, Ian S, Vinogradov, Sophia   +7 more
core   +2 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Ethical and social issues of personalized medicine [PDF]

, 2017
A medicina personalizada tem como objetivo integrar a informação genética do indivíduo, os fatores ambientais a que este está exposto e o seu estilo de vida para identificar a sua predisposição à doença e as medidas preventivas, de promoção da saúde e
Alexander Brunker, Frank Gauterin, Michael Frey, Thomas Wohlgemuth   +3 more
core   +2 more sources