Results 91 to 100 of about 6,201,030 (283)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Embodied perspective-taking indicated by selective disruption from aberrant self motion [PDF]

, 2016
Spatial perspective-taking that involves imagined changes in one’s spatial orientation is facilitated by vestibular stimulation inducing a congruent sensation of self-motion.
Stent, C., Christine Mohr, Gardner, M., John F. Golding, Mohr, C., Golding, J.F., Mark R. Gardner, Chloé Stent, Stent C, Golding JF, Gardner MR, Mohr C   +11 more
core   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Spatial perspective taking is distinct from cognitive and affective perspective taking.

Journal of Experimental Psychology: General
Abstract Perspective taking (PT) is the ability to imagine viewpoints different from our own. However, the nature of PT as a construct, and its underlying cognitive mechanisms, are not well established. Some researchers propose that understanding what others believe (cognitive PT), feel (affective PT), and see (spatial PT) form a single
Maria Brucato, Nora S. Newcombe, Jason Chein   +2 more
openaire   +2 more sources

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

One small step outside the here and now: what stories can tell us about children’s perspective-taking

, 2015
The enjoyment of fiction and narrative depends on our ability to step outside our own perspective and take that of another person in a different spatial and temporal reference frame.
Fenja Ziegler (17170813)
core   +4 more sources

PISA 2022 insights on intellectual curiosity, perspective-taking, and science achievement: Examining the mediating pathways

International Journal of Educational Research Open
The purpose of the study is to investigate the predictive roles of intellectual curiosity and perspective-taking on science achievement among Emirati early adolescents. Utilizing data from 24,600 participants of the 2022 Program for International Student
Othman Abu Khurma, Adeeb Jarrah, Nagla Ali   +2 more
doaj   +1 more source

The Effect of Social Perspective-Taking on Interpersonal Trust Under the Cooperative and Competitive Contexts: The Mediating Role of Benevolence

, 2021
Binghai Sun, Xiajun Yu, Xuhui Yuan, Changkang Sun, Weijian Li School of Teacher Education, Zhejiang Normal University, Jinhua, 321004, People’s Republic of ChinaCorrespondence: Xuhui Yuan; Changkang SunSchool of Teacher Education, Zhejiang Normal ...
Li W, Sun B, Sun C, Yuan X, Yu X
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source