Results 81 to 90 of about 3,929,932 (291)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Les macaques de Tonkéan perçoivent-ils ce que peuvent et ne peuvent pas voir leurs congénères ?

Revue de Primatologie, 2015
La capacité à percevoir ce que peut voir ou ne peut pas voir autrui, i.e.  « perspective-taking » visuel, est un prérequis à la Théorie de l’Esprit. Alors que l'existence du « perspective-taking » a été de nombreuses fois prouvée chez les grands singes ...
Charlotte Canteloup, Emilie Piraux, Helene Meunier   +2 more
doaj   +1 more source

Strategy modulates spatial perspective-taking: Evidence for dissociable disembodied and embodied routes [PDF]

, 2013
Previous research provides evidence for a dissociable embodied route to spatial perspective-taking that is under strategic control. The present experiment investigated further the influence of strategy on spatial perspective-taking by assessing whether ...
Mark eGardner, Mark eBrazier, Petra eGronholm, Edmonds, Caroline J., Gronholm, Petra C., Gronholm, P.C., Caroline Jane Edmonds, Gardner, Mark R, Brazier, M., Gronholm, Petra C.; id_orcid, Edmonds, Caroline, Edmonds, C.J., Gardner, M., Gardner, Mark R., Brazier, Mark   +14 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

空間的視点取得の視点方向別反応時間にみられる特性 [PDF]

, 2001
Departmental Bulletin PaperReaction　time　as　a　function　of　rotation angle　in　spatial　perspective-taking　was　investigated with　an　original　perspective-taking　task.　Relation　between　reaction　time　and　rotation　angle was　assumed　to　indicate　characteristics　
渡部, 雅之
core  

Inclined to see it your way: do altercentric intrusion effects in visual perspective taking reflect an intrinsically social process? [PDF]

, 2015
It has been suggested that some aspects of mental state understanding recruit a rudimentary, but fast and efficient, processing system, demonstrated by the obligatory slowing down of judgements about what the self can see when this is incongruent with ...
Nielsen, M., Holmes, A., Slade, L., Levy, J.   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Faktor Eksternal dari Orangtua atau Faktor Internal Diri Sendiri yang Memprediksi Emosi Moral Remaja?

Intuisi, 2020
Emosi moral memegang peran penting yang berfungsi sebagai motif munculnya kecenderungan tindakan moral dan mengantisipasi pelanggaran moral remaja, dan mampu memikirkan kesejahteraan orang lain.
Margaretha Maria Shinta Pratiwi, Subandi Subandi, Maria Goretti Adiyanti   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source