Results 61 to 70 of about 6,201,030 (283)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A randomized pragmatic feasibility trial to promote student perspective-taking on client physical activity level: a collaborative project

Pilot and Feasibility Studies
Background Health-care practitioners have opportunities to talk with clients about unhealthy behaviors. How practitioners approach these conversations involves skill to be effective.
Lisa B. Hoplock, Michelle M. Lobchuk, Shaelyn M. Strachan, Gayle Halas, Cheryl Olfert, Sandra Webber, Joanne L. Parsons   +6 more
doaj   +1 more source

Interacting Timescales in Perspective-Taking [PDF]

Frontiers in Psychology, 2018
Through theoretical discussion, literature review, and a computational model, this paper poses a challenge to the notion that perspective-taking involves a fixed architecture in which particular processes have priority. For example, some research suggests that egocentric perspectives can arise more quickly, with other perspectives (such as of task ...
Rick Dale, Rick Dale, Alexia Galati, Alexia Galati, Alexia Galati, Camila Alviar, Camila Alviar, Pablo Contreras Kallens, Pablo Contreras Kallens, Pablo Contreras Kallens, Adolfo G. Ramirez-Aristizabal, Maryam Tabatabaeian, David W. Vinson   +12 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of a perspective-taking intervention on the consideration of pain assessment and treatment decisions

, 2015
Objectives: Pain is often poorly managed, highlighting the need to better understand and treat patients' pain. Research suggests that pain is assessed and treated differently depending on patient sex, race, and/or age.
George, Steven Z., Torres, Calia A., Robinson, Michael E., Wandner, Laura D., Bartley, Emily J., Robinson ME, Wandner LD, Torres CA, Bartley EJ, George SZ   +9 more
core   +2 more sources

How culture influences perspective taking: Differences in correction, not integration

Frontiers in Human Neuroscience, 2013
Individuals from East Asian (Chinese) backgrounds have been shown to exhibit greater sensitivity to a speaker's perspective than Western (US) participants when resolving referentially ambiguous expressions. We show that this cultural difference does
Shali eWu, Dale J Barr, Timothy Matthew Gann, Boaz eKeysar   +3 more
doaj   +1 more source

Perspective taking, pictures, and the blind [PDF]

Perception & Psychophysics, 1990
Congenitally blind, late blind, and blindfolded sighted controls attempted a Piagetian perspective-taking (three-mountain) task. Piaget used the term perspective to mean point of view (Piaget & Inhelder, 1967, p. 210), and the present usage does not imply linear perspective.
M A, Heller, J M, Kennedy
openaire   +2 more sources

Strategy modulates spatial perspective-taking: Evidence for dissociable disembodied and embodied routes [PDF]

, 2013
Previous research provides evidence for a dissociable embodied route to spatial perspective-taking that is under strategic control. The present experiment investigated further the influence of strategy on spatial perspective-taking by assessing whether ...
Mark eGardner, Mark eBrazier, Petra eGronholm, Edmonds, Caroline J., Gronholm, Petra C., Gronholm, P.C., Caroline Jane Edmonds, Gardner, Mark R, Brazier, M., Gronholm, Petra C.; id_orcid, Edmonds, Caroline, Edmonds, C.J., Gardner, M., Gardner, Mark R., Brazier, Mark, Mark Brazier, Caroline J. Edmonds, Mark R. Gardner, Petra C. Gronholm   +18 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source