Results 91 to 100 of about 2,646,607 (294)
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Lead-it-EAZY! GMP-compliant production of [212Pb]Pb-PSC-PEG2-TOC
EJNMMI Radiopharmacy and ChemistryBackground Recently, radiotheranostics comprising the true matched radionuclide pair 203/212Pb could serve as real dosimetric planning utility using 203Pb-radiolabelled pharmaceuticals before therapy with 212Pb-radiolabelled counterparts. 212Pb might act
Marc Pretze +6 more
doaj +1 more source
The Service for the Customers of Coal Products in the Context of the Conception of Relationship Marketing [PDF]
Bìznes Inform, 2017 The article is aimed at developing approaches to the service for various groups of customers of coal products in the context of the conception of relationship marketing.
Trushkina Nataliia V.
doaj
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Conjoncture et structures : les perspectives spatiales du plein-emploi au Canada [PDF]
, 1956 Pierre D. Harvey
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Logistics Concepts at the Industrial Enterprise under Conditions of the Globalization of Markets [PDF]
Problemi Ekonomiki, 2016 The aim of the article is to assess the dynamics of indicators of Ukraine’s foreign trade in goods and services; conduct a comparative analysis of logistics concepts used at industrial enterprises under conditions of the globalization of markets ...
Trushkina Nataliia V. +2 more
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