Results 101 to 110 of about 2,646,607 (294)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

THE WAYS OF IMPROVING METHODICAL BASIS AND INSTRUMENTAL TOOLS OF DECISION MAKING PROCESSES SUPPORT WITHIN THE NATIONAL SECURITY SYSTEM

open access: yesSučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015
During researches is proposed the model of the automated decision-making from substantiate of the strategic objectives for the subjects of the national security system (NSS).
Volodymyr Y. Bohdanovych   +2 more
doaj  

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

Triangles Triply in Perspective [PDF]

open access: bronze, 1909
Charles M‘Leod, William P. Milne
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Perspectives [PDF]

open access: yesHistory of Education Quarterly, 1961
openaire   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Physical literacy-based intervention for chronic disease management: a quasi-experimental study protocol

open access: yesBMC Sports Science, Medicine and Rehabilitation
Background As chronic diseases proliferate globally, innovative interventions that promote sustainable physical activity are crucial. Physical literacy offers a holistic strategy for the promotion of lifelong health.
Alexandre Mouton   +2 more
doaj   +1 more source

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