Results 91 to 100 of about 505,854 (305)

Limited discrepancy AND/OR search and its application to optimization tasks in graphical models [PDF]

open access: yes, 2016
Many combinatorial problems are solved with a Depth-First search (DFS) guided by a heuristic and it is well-known that this method is very fragile with respect to heuristic mistakes.
Dechter, Rina   +2 more
core  

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Complementary wave solutions for the long-short wave resonance model via the extended trial equation method and the generalized Kudryashov method

open access: yesOpen Physics, 2018
In this paper the nonlinear long-short (LS) wave resonance model is analyzed through a new perspective. We obtain the classification of exact solutions by making use of the complete discrimination system for the trial equation method and through the ...
Cimpoiasu Rodica, Pauna Alina Streche
doaj   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

open access: yesFEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh   +2 more
wiley   +1 more source

The Bayes Tree: Enabling Incremental Reordering and Fluid Relinearization for Online Mapping [PDF]

open access: yes, 2010
In this paper we present a novel data structure, the Bayes tree, which exploits the connections between graphical model inference and sparse linear algebra.
Dellaert, Frank   +3 more
core   +1 more source

Most autophagic cell death studies lack evidence of causality

open access: yesFEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Designing by Geometry. Rankine's Theorems of Transformation of Structures. [PDF]

open access: yes, 2010
William John Macquorn Rankine (1820-1872) was one of the main figures in establishing engineering science in the second half of the 19th. Century. His Manual of Applied Mechanics (1858) gathers most of his contributions to strength of materials and ...
Huerta Fernández, Santiago
core   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

Introduction: New Perspectives on Swiss Graphic Design [PDF]

open access: yesDesign Issues, 2021
Fornari, Davide   +5 more
openaire   +3 more sources

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