Results 91 to 100 of about 4,354,487 (343)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Effects of Stereoscopic 3D Contents on the Process of Learning to Build a Handmade PC

open access: yesKnowledge Management & E-Learning: An International Journal, 2011
We previously developed Web3D contents that simulate the procedure for assembling a handmade PC. The original motivation for this project was to enable media-informatics students to deepen their understanding of PC hardware.
Tosh Yamamoto   +4 more
doaj  

A comparative study of YOLOv5 and YOLOv8 for corrosion segmentation tasks in metal surfaces

open access: yesArray
This study delves into the comparative efficacy of YOLOv5 and YOLOv8 in corrosion segmentation tasks. We employed three unique datasets, comprising 4942, 5501, and 6136 images, aiming to thoroughly evaluate the models’ adaptability and robustness in ...
Edmundo Casas   +3 more
doaj   +1 more source

An Exercise in Invariant-based Programming with Interactive and Automatic Theorem Prover Support

open access: yes, 2012
Invariant-Based Programming (IBP) is a diagram-based correct-by-construction programming methodology in which the program is structured around the invariants, which are additionally formulated before the actual code.
Back, Ralph-Johan, Eriksson, Johannes
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Utilisation de plans forestiers XVIIIe- XIXe siècles pour une étude archéologique des paysages passés de la forêt de Chailluz (Besançon) : l’exemple d’un réseau viaire

open access: yesBulletin du Centre d’Études Médiévales d’Auxerre, 2015
Today Besancon has the highest percentage of green space per inhabitant among France’s largest cities (200 m2 per capita). 3/4 of it are made up by the Forêt de Chailluz (16.7 km2), a large forest which has maintained its present extent for over six ...
Catherine Fruchart
doaj   +1 more source

Think Spatially With Game Engine

open access: yesISPRS International Journal of Geo-Information, 2020
Spatial thinking and spatial orientation skills are involved in tasks related to the recognition of landforms, mapping, spatial interpretation, and landscape analysis, and can be developed with specific training.
Carlos Carbonell-Carrera   +3 more
doaj   +1 more source

When is a Network a Network? Multi-Order Graphical Model Selection in Pathways and Temporal Networks

open access: yes, 2017
We introduce a framework for the modeling of sequential data capturing pathways of varying lengths observed in a network. Such data are important, e.g., when studying click streams in information networks, travel patterns in transportation systems ...
Costa Alceu Ferraz   +2 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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