Results 81 to 90 of about 4,354,487 (343)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Composing high-level stream processing pipelines
Journal of Big Data, 2020 The growing number of Internet of Things (IoT) devices provide a massive pool of sensing data. However, turning data into actionable insights is not a trivial task, especially in the context of IoT, where application development itself is complex.
Tanmaya Mahapatra
doaj +1 more source
Neural Ideal Point Estimation Network
, 2018 Understanding politics is challenging because the politics take the influence from everything. Even we limit ourselves to the political context in the legislative processes; we need a better understanding of latent factors, such as legislators, bills ...
Lee, Wonsung +2 more
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Química NovaRelevant historical aspects concerning ideal gases were briefly reviewed to provide a condensed resource for the undergraduate student of chemistry. The importance of the barometer and the concept of atmospheric pressure were reviewed and discussed.
Leonardo M. Da Silva +1 more
doaj +1 more source
Głos w dyskusji o tekście staropolskim. Znad kanonów mszy św.
LingVaria, 2017 A Contribution to the Discussion on Old Polish Text. Analysing the Canons of the Mass The paper analyses selected mediaeval Canons of the Mass from a text linguisctic perspective.
Dorota Masłej
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
¿Qué es calidad de vida para un paciente con cáncer?
Avances en Psicología Latinoamericana, 2015 Objective: To evaluate the concept of quality of life from the patient´s perspective. Method: 1029 patients having different diagnoses of cancer were evaluated using an open-ended question (How would you define Quality of Life?).
Ricardo Sánchez +2 more
doaj +1 more source
An omics perspective on drug target discovery platforms
Briefings Bioinform., 2019 The drug discovery process starts with identification of a disease-modifying target. This critical step traditionally begins with manual investigation of scientific literature and biomedical databases to gather evidence linking molecular target to ...
J. Paananen, V. Fortino
semanticscholar +1 more source