Results 11 to 20 of about 1,081 (154)

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors [PDF]

Frontiers in Physiology
Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi, Eita Sasaki, Hisashi Ohno, Orie Takayama, Sota Yamada, Kenjiro Hanaoka, Kenjiro Hanaoka   +6 more
doaj   +2 more sources

Mechanism of Intracellular Elemental Sulfur Oxidation in Beggiatoa leptomitoformis, Where Persulfide Dioxygenase Plays a Key Role. [PDF]

Int J Mol Sci
Representatives of the colorless sulfur bacteria of the genus Beggiatoa use reduced sulfur compounds in the processes of lithotrophic growth, which is accompanied by the storage of intracellular sulfur. However, it is still unknown how the transformation of intracellular sulfur occurs in Beggiatoa representatives.
Rudenko TS, Trubitsina LI, Terentyev VV, Trubitsin IV, Borshchevskiy VI, Tishchenko SV, Gabdulkhakov AG, Leontievsky AA, Grabovich MY.   +8 more
europepmc   +3 more sources

Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study [PDF]

Discover Oncology
Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. Methods Summary-level
Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu   +6 more
doaj   +2 more sources

Ethylmalonic encephalopathy caused by biallelic truncating variants in ETHE1: A case report [PDF]

SAGE Open Medical Case Reports
Ethylmalonic encephalopathy is a rare autosomal recessive mitochondrial disorder caused by biallelic pathogenic variants in ETHE1 , the gene encoding mitochondrial persulfide dioxygenase, an enzyme crucial for hydrogen sulfide (H 2 S) detoxification ...
Delmer-Alejandro Ruiz-Martinez, Emilio-Rodrigo Vega-Peniche, Yazmin Quiñonez-Pacheco, Hugo Laviada-Molina, Carlos-Alejandro Medina-Campos, Felix-Julian Campos-Garcia   +5 more
doaj   +2 more sources

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome [PDF]

, 2017
Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase (
Barriocanal-Casado, Eliana, Chaves-Serrano, Julio, Hidalgo-Gutierrez, Agustin, Hildebrandt, Tatjana M., Luna-Sanchez, Marta, Schuelke, Markus [u.a.]   +5 more
core   +8 more sources

Rhodaneses minimize the accumulation of cellular sulfane sulfur to avoid disulfide stress during sulfide oxidation in bacteria

Redox Biology, 2022
Heterotrophic bacteria and human mitochondria often use sulfide: quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO) to oxidize sulfide to sulfite and thiosulfate.
Mingxue Ran, Qingbin Li, Yufeng Xin, Shaohua Ma, Rui Zhao, Min Wang, Luying Xun, Yongzhen Xia   +7 more
doaj   +1 more source

Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1 [PDF]

Biochemical and Biophysical Research Communications, 2016
Reactive persulfide species such as glutathione persulfide (GSSH) are highly abundant biomolecules. Persulfide dioxygenase (also called ethylmalonic encephalopathy protein 1, ETHE1) reportedly metabolizes GSSH to GSH with simultaneous oxygen consumption. How ETHE1 activity is regulated is still unclear, however.
Minkyung Jung, Shingo Kasamatsu, Tetsuro Matsunaga, Soichiro Akashi, Katsuhiko Ono, Akira Nishimura, Masanobu Morita, Hisyam Abdul Hamid, Shigemoto Fujii, Hiroshi Kitamura, Tomohiro Sawa, Tomoaki Ida, Hozumi Motohashi, Takaaki Akaike   +13 more
openaire   +2 more sources

Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-β-lactamase Superfamily [PDF]

Journal of Biological Chemistry, 2015
Persulfide dioxygenases (PDOs), also known as sulfur dioxygenases (SDOs), oxidize glutathione persulfide (GSSH) to sulfite and GSH. PDOs belong to the metallo-β-lactamase superfamily and play critical roles in animals, plants, and microorganisms, including sulfide detoxification.
Sattler, Steven A, Wang, Xia, Lewis, Kevin M, DeHan, Preston J, Park, Chung-Min, Xin, Yufeng, Liu, Honglei, Xian, Ming, Xun, Luying, Kang, ChulHee   +9 more
openaire   +3 more sources

The Response of Acinetobacter baumannii to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation

mBio, 2020
Acinetobacter baumannii is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. A.
Brenna J. C. Walsh, Jiefei Wang, Katherine A. Edmonds, Lauren D. Palmer, Yixiang Zhang, Jonathan C. Trinidad, Eric P. Skaar, David P. Giedroc   +7 more
doaj   +1 more source

Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H2S lead to H2S deficiency in calcific aortic valve disease

Redox Biology, 2023
Hydrogen sulfide (H2S) was previously revealed to inhibit osteoblastic differentiation of valvular interstitial cells (VICs), a pathological feature in calcific aortic valve disease (CAVD).
Zsolt Combi, László Potor, Péter Nagy, Katalin Éva Sikura, Tamás Ditrói, Eszter Petra Jurányi, Klaudia Galambos, Tamás Szerafin, Péter Gergely, Matthew Whiteman, Roberta Torregrossa, Yuchao Ding, Lívia Beke, Zoltán Hendrik, Gábor Méhes, György Balla, József Balla   +16 more
doaj   +1 more source