Results 51 to 60 of about 1,081 (154)

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026.
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Cysteine Signalling in Plant Pathogen Response

Plant, Cell &Environment, Volume 48, Issue 10, Page 7107-7122, October 2025.
ABSTRACT The amino acid cysteine is the precursor for a wide range of sulfur‐containing functional molecules in plants, including enzyme cofactors and defence compounds. Due to its redox active thiol group cysteine is highly reactive. Synthesis and degradation pathways are present in several subcellular compartments to adjust the intracellular cysteine
Jannis Moormann, Björn Heinemann, Cecile Angermann, Anna Koprivova, Ute Armbruster, Stanislav Kopriva, Tatjana M. Hildebrandt   +6 more
wiley   +1 more source

Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway [PDF]

, 2017
Coenzyme Q (CoQ) is an electron acceptor for sulfide‐quinone reductase (SQR), the first enzyme of the hydrogen sulfide oxidation pathway. Here, we show that lack of CoQ in human skin fibroblasts causes impairment of hydrogen sulfide oxidation ...
Barca, Emanuele, Di Meo, Ivano, Gao, Xing-Huang, Kleiner, Giulio, Sanchez-Quintero, Maria J., Schuelke, Markus, Tadesse, Saba, Ziosi, Marcello   +7 more
core   +1 more source

Comparative Embryology and Transcriptomics of Asellus infernus, an Isopod Crustacean From Sulfidic Groundwater

Evolution &Development, Volume 27, Issue 3, September 2025.
Individuals of Asellus infernus, a sulfidic subterranean population of the Asellus aquaticus species complex from southeastern Romania (left) and surface individuals of A. aquaticus (right). Extreme differences in phenotype are seen comparing the subterranean and surface individuals as adults (top panels) and as embryonic samples (bottom panels ...
Haeli J. Lomheim, Lizet Reyes Rodas, Devon Price, Serban M. Sarbu, Raluca I. Băncilă, Cody Carroll, Layla Freeborn, Sheri Sanders, Meredith E. Protas   +8 more
wiley   +1 more source

Mobilization of sulfane sulfur from cysteine desulfurases to the Azotobacter vinelandii sulfurtransferase RhdA [PDF]

, 2011
Mobilization of the l-cysteine sulfur for the persulfuration of the rhodanese of Azotobacter vinelandii, RhdA, can be mediated by the A. vinelandii cysteine desulfurases, IscS and NifS.
F. Cartini, F. Forlani, J. Papenbrock, P. C. Dos Santos, S. Pagani, W. Remelli   +5 more
core   +1 more source

Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine [PDF]

, 2022
Funding Information: This research was supported by Fundação para a Ciência e Tecnologia (PTDC/MED-TOX/30418/2017) and iNOVA4Health (UID/Multi/04462/2013). M.J.C., D.G.F.F. and J.M.
Almeida, Manuel S., Antunes, Alexandra M.M., Branco, Patrícia, Calado, Joaquim, Correia, Maria João, Fernandes, Dalila G.F., Monteiro, Emília C., Morello, Judit, Pereira, Sofia A., Pimpão, António B., Sequeira, Catarina O., Serpa, Jacinta, Vicente, João B.   +12 more
core   +1 more source

In Hyphomicrobium denitrificans Two Related Sulfane‐Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses

Molecular Microbiology, Volume 124, Issue 3, Page 204-220, September 2025.
In Hyphomicrobium denitrificans, the use of thiosulfate as a supplemental electron donor is regulated by two homologous sulfane‐sulfur responsive ArsR‐type transcriptional repressors, sHdrR and SoxR, that act cooperatively. Remarkably, the regulation by sHdrR/SoxR extends far beyond sulfur oxidation and deeply affects anaerobic metabolism, particularly
Jingjing Li, Nora E. Schmitte, Kaya Törkel, Christiane Dahl   +3 more
wiley   +1 more source

Atomic sulfur : an element for adaptation to an oxidative environment [PDF]

, 2017
During the period of rising oxygen concentration in the Earth’s atmosphere (Figure 1), sulfur atoms were incorporated into proteins as redox-active cysteine residues [1] and antioxidant molecules such as thioredoxin, glutathione, and glutaredoxin ...
Nagahara, Noryuki, Wróbel, Maria
core   +2 more sources

Mendelian Randomization Analysis of Mitochondria‐Related Genes and Screening of Prognostic Genes in Colorectal Cancer

Cancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Background Mitochondria have been linked with inflammatory colorectal cancer (CRC) development; however, the association between mitochondria‐related genes (MRGs) and CRC remains unknown. Aims To explore the causal relationship between MRGs and CRC, screen prognostic genes, conduct drug prediction analyses, and investigate the correlations ...
Limin Zhu, Xiaowei Huang, Fan Zhang, Jinzu Yang, Zhenye Xu   +4 more
wiley   +1 more source