Results 161 to 170 of about 166,888 (204)

On the Toxin of Haem. Pertussis

Journal of the Japanese Association for Infectious Diseases, 1951
Kuwashima, Yasuo, Iwamura, Kaneaki, Hirai, Tsutomu   +2 more
openaire   +1 more source

Safety and immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin administered to pregnant women living with and without HIV and their newborns (WoMANPOWER): a randomised controlled trial in Uganda.

Lancet Glob Health
Nakabembe E, Greenland M, Amaral K, Abu-Raya B, Amone A, Andrews N, Cantrell L, Lesne E, Gorringe A, Halkerston R, Mcstraw N, Dixon L, Hunter OF, Heath PT, Imede E, Kyohere M, Musoke P, Nakimuli A, Sekikubo M, Taylor S, Tusubira V, Sadarangani M, Le Doare K.   +22 more
europepmc   +1 more source

The crystal structure of pertussis toxin [PDF]

Structure, 1994
Pertussis toxin is an exotoxin of the A-B class produced by Bordetella pertussis. The holotoxin comprises 952 residues forming six subunits (five different sequences, S1-S5). It plays an important role in the development of protective immunity to whooping cough, and is an essential component of new acellular vaccines.
Randy Read, Penelope E Stein, Glen D Armstrong   +2 more
exaly   +3 more sources

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Pertussis toxin (Bordetella pertussis)

1997
Abstract PT (Sekura et al. 1985) is a protein of 105 000 daltons composed of five noncovalently linked subunits named 51 through 55, and organized into two functional domains called A and B (Tamura et al. 1982). The A domain, which is composed of the 51 subunit, is an enzyme that intoxicates eukaryotic cells by ADP-ribosylating their GTP¬
R Rappuoli, M G Pizza
openaire   +1 more source

Binding of NAD+ to pertussis toxin

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1991
The equilibrium dissociation constant of NAD+ and pertussis toxin was determined by equilibrium dialysis and by the quenching of the protein's intrinsic fluorescence on titration with NAD+. A binding constant, Kd, of 24 +/- 2 microM at 30 degrees C was obtained from equilibrium dialysis, consistent with the previously determined value for the Michaelis
M D, Lobban, L I, Irons, S, van Heyningen   +2 more
openaire   +2 more sources

Production of cell mass and pertussis toxin by Bordetella pertussis

Journal of Biotechnology, 1991
The cultivation of Bordetella pertussis affects production of pertussis toxin and biomass. Comparison of batch mode, chemostat operation and pHstat-turbidostatic control showed that productivities for the continuous process were greater than that for the batch operation.
P, Licari, G R, Siber, R, Swartz
openaire   +2 more sources

The effect of pH on the production of pertussis toxin by Bordetella pertussis

Journal of Biotechnology, 1991
The production of pertussis toxin by Bordetella pertussis was increased by controlling the pH at 7.0 through the addition of sulfuric acid. The more commonly used hydrochloric acid and Tris buffer were observed to be detrimental to toxin yields.
P, Licari, L, Winberry, R, Swartz
openaire   +2 more sources

The role of pertussis toxin in clinical manifestations of pertussis

Toxicon
Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis (B. pertussis). In recent years, the resurgence of pertussis has once again drawn widespread attention from the academic community and society at large. The pathogenicity of B.
Wenjuan, Zhao, Meng, Dang, Shuyue, Tang, Min, Hao, Zengguo, Wang   +4 more
openaire   +2 more sources

Bordetella pertussis toxins

Pharmacology & Therapeutics, 1982
A C, Wardlaw, R, Parton
openaire   +2 more sources

Paradoxes of Pertussis Toxin

Zentralblatt für Bakteriologie, 1990
openaire   +2 more sources