Results 61 to 70 of about 645,718 (276)

The role of B. pertussis vaccine antigen gene variants in pertussis resurgence and possible consequences for vaccine development [PDF]

, 2016
Whooping cough, or pertussis, caused by Bordetella pertussis is considered resurgent in a number of countries world-wide, despite continued high level vaccine coverage.
Preston, Andrew
core   +1 more source

Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzae Type B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age

Canadian Journal of Infectious Diseases and Medical Microbiology, 2007
OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine, Haemophilus influenzae type b (DTaP ...
Ronald Gold, Luis Barreto, Santiago Ferro, John Thippawong, Roland Guasparini, William Meekison, Margaret Russell, Elaine Mills, Dana Harrison, Pierre Lavigne   +9 more
doaj   +1 more source

A new socioeconomic status measure for vaccine research in children using individual housing data: a population-based case-control study

BMC Public Health, 2016
Background We recently developed HOUSES, an individual housing-based socioeconomic status (SES) measurement for health disparities research. We assessed whether HOUSES was associated with risk of pertussis and pertussis vaccine up-to-date status in ...
Rachel Hammer, Conrad Capili, Chung-Il Wi, Euijung Ryu, Jennifer Rand-Weaver, Young J. Juhn   +5 more
doaj   +1 more source

Effect of FHA and Prn on Bordetella pertussis colonization of mice is dependent on vaccine type and anatomical site.

PLoS ONE, 2020
Bordetella pertussis vaccine escape mutants that lack expression of the pertussis antigen pertactin (Prn) have emerged in vaccinated populations in the last 10-20 years.
Anne Zeddeman, Evi van Schuppen, Kristianne E Kok, Marjolein van Gent, Kees J Heuvelman, Marieke J Bart, Han G J van der Heide, Joshua Gillard, Elles Simonetti, Marc J Eleveld, Fred J H van Opzeeland, Saskia van Selm, Ronald de Groot, Marien I de Jonge, Frits R Mooi, Dimitri A Diavatopoulos   +15 more
doaj   +1 more source

Differential and Temporal Immunomodulation of alpha4 Integrins on CD4+ Memory Cells by Bordetella pertussis and Bordetella parapertussis [PDF]

, 2012
Pertussis, caused by Bordetella pertussis (B. pertussis), is reemerging worldwide due to vaccine inefficacy. The hallmarks of infection are extreme lymphocytosis and delayed recovery, which are partially associated with pertussis toxin.
Ravindra, Dipti
core   +1 more source

Clinical progress note: Pertussis

Journal of Hospital Medicine, EarlyView.
Abstract Pertussis, commonly known as whooping cough, is a vaccine‐preventable respiratory disease with rising incidence due to declining vaccination rates and waning immunity. The most severe disease course is seen in unvaccinated or incompletely vaccinated infants less than 2 months of age, accounting for the largest burden of hospitalization and ...
Samantha Hanna, Nicole Samies
wiley   +1 more source

A solid approach to biopharmaceutical stabilisation [PDF]

, 2018
Ensilication is a technology we developed that can physically stabilise proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by tailor fitting individual proteins with a silica coat using a modified sol-gel process. Biopharmaceuticals, for example, liquid-formulated vaccines with adjuvants, have poor thermal stability ...
arxiv   +1 more source

Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future. [PDF]

, 2017
The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages ...
Miller, Lisa, Pinkerton, Kent, Royer, Christopher, Schelegle, Edward   +3 more
core   +1 more source

Clinical characteristics and risk factors of severe bocavirus‐positive pneumonia in children and a literature review

Pediatric Discovery, EarlyView.
The study explored the clinical characteristics and risk factors of HBoV‐positive severe pneumonia in children. These findings indicate that HBoV can be identified in respiratory samples from children with severe pneumonia, denoting its role as a viral pathogen in hospitalized children with this condition.
Jing Liao, Zhongying Yang, Yu He, Jianhua Wei, Luo Ren, Enmei Liu, Na Zang   +6 more
wiley   +1 more source

The Impact of Vaccination Behavior on Disease Spreading Based on Complex Networks [PDF]

arXiv, 2021
Vaccination is an effective way to prevent and control the occurrence and epidemic of infectious diseases. However, many factors influence whether the residents decide to get vaccinated or not, such as the efficacy and side effects while individuals hope to obtain immunity through vaccination.
arxiv