Results 171 to 180 of about 110,621 (200)

Copper and Gallium PET Imaging Agents for Applications in HIV and Cancer

2021
Positron emission tomography (PET) is a sensitive nuclear imaging technique that can highlight physiological and biochemical processes in vivo. If we extend the current utility of PET, we can both diagnose disease earlier, and improve our understanding of disease evolution. This thesis represents an investigation into PET applications in HIV and cancer,
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Site-specific 68Ga-labeled Annexin A5 as a PET imaging agent for apoptosis

Nuclear Medicine and Biology, 2011
Two variants of Annexin A5 (Cys2-AnxA5 and Cys165-AnxA5) were labelled with Gallium-68 in order to evaluate their biological properties.Biodistribution and pharmacokinetics of the radiotracers were studied with μPET in healthy mice and in a mouse model of hepatic apoptosis.
Bauwens, Matthias, De Saint-Hubert, Marijke, Devos, Ellen, Deckers, Niko, Reutelingsperger, Chris P. M., Mortelmans, Luc, Himmelreich, Uwe, Mottaghy, Felix M., Verbruggen, Alfons M.   +8 more
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Developing a cassette microdosing approach to enhance the throughput of PET imaging agent screening

Journal of Pharmaceutical and Biomedical Analysis, 2018
Cassette dosing is also known as N-in-One dosing: several compounds are simultaneously administrated to a single animal and then the samples are rapidly detected by LC-MS/MS. This approach is a successful strategy to enhance the efficiency of drug discovery and reduce animal usage.
Hao, Xiao, Mingyue, Sun, Ruiyue, Zhao, Haiyan, Hong, Aili, Zhang, Shuxian, Zhang, Futao, Liu, Yan, Zhang, Yajing, Liu, Lin, Zhu, Hank F, Kung, Jinping, Qiao   +11 more
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Radiosynthesis and in vivo evaluation of [11C]MOV as a PET imaging agent for COX-2

Bioorganic & Medicinal Chemistry Letters, 2018
Radiosynthesis and in vivo evaluation of [11C]4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (methoxy analogue of valdecoxib, [11C]MOV), a COX-2 inhibitor, was conducted in rat and baboon. Synthesis of the reference standard MOV (3), and its desmethyl precursor 2 for radiolabeling were performed using 1,2-diphenylethan-1 ...
Jaya, Prabhakaran, Mark, Underwood, Francesca, Zanderigo, Norman R, Simpson, Anna R, Cooper, Jeffrey, Matthew, Harry, Rubin-Falcone, Ramin V, Parsey, J John, Mann, J S, Dileep Kumar   +9 more
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Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues

Bioorganic & Medicinal Chemistry Letters, 2004
Radiolabeled antimitotic agents [11C]T138067 and [18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1alpha implanted athymic mice and MDA ...
Xiangshu, Fei, Qi-Huang, Zheng, Ji-Quan, Wang, K Lee, Stone, Tanya D, Martinez, Kathy D, Miller, George W, Sledge, Gary D, Hutchins   +7 more
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Recent Developments of the PET Imaging Agents for Metabotropic Glutamate Receptor Subtype 5

Current Topics in Medicinal Chemistry, 2007
Glutamate is a major excitatory neurotransmitter in central nervous system (CNS) acting through ionotropic and G-protein coupled metabotropic glutamate receptors. Metabotropic glutamate receptor 5 (mGluR5), a subtype in the group I mGluRs, presents in high density in many brain regions (hippocampus, cortex and olfactory system).
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WITHDRAWN:New PET imaging agents in the management of solid cancers.

Current opinion in oncology
Ahead of Print article withdrawn by publisher.
Camilo, Garcia, Geraldine, Gebhart, Patrick, Flamen   +2 more
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Phosphoramidate-based Peptidomimetic Prostate Cancer PET Imaging Agents

2013
Abstract : The main goal is to develop a PET imaging agent based on modifying the peptidomimetic PSMA inhibitor which will result in improved tumor uptake and clearance mechanism. Different fluorination approaches were attempted with PSMA module compounds such as direct labeling, cupper free chemistry and the use of prosthetic group (SFB).
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SVCT2-targeted PET imaging agent for the evaluation of LN metastasis of thyroid cancer

Bioorganic Chemistry
Cervical lymph node (LN) metastasis is highly prevalent in thyroid cancer (TC). However, the lack of diagnostic modalities that enable real-time assessment of LN metastasis remains a challenge in providing efficient clinical decision-making and optimal patient care.
Lei, Peng, Songhan, Ge, Tianhong, Yang, Yali, Long, Hui, Nie, Zhengkun, Zhang, Renbo, Wu, Dake, Zhang, Fuhua, Wen, Qiao, He, Jianbo, Liu, Xiangsong, Zhang, Zhihao, Zha   +12 more
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Macrocyclic complexes, their process of preparation and use as PET imaging agents

2016
The present invention concerns compounds of formula (I):their process of preparation and compositions thereof. The present invention also concerns their use as diagnostic agent in PET imaging.
Gaumet, Vincent, Denis, Claire, Vidal, Aurélien, Auzeloux, Philippe, Madelmont, Jean-Claude, Miot - Noirault, Elisabeth, Chezal, Jean Michel   +6 more
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