Results 161 to 170 of about 110,621 (200)
Some of the next articles are maybe not open access.
AAZTA: An Ideal Chelating Agent for the Development of 44Sc PET Imaging Agents
Angewandte Chemie International Edition, 2017AbstractUnprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4‐bis(carboxymethyl)‐6‐[bis(carboxymethyl)]amino‐6‐methylperhydro‐1,4‐diazepine) under mild experimental conditions. The robustness of the 44Sc(AAZTA)− chelate and conjugated biomolecules thereof is further shown by in vivo PET ...
Gábor Nagy +13 more
openaire +3 more sources
PET imaging agents targeting macrophage surface receptors
Chinese Science Bulletin, 2019Inflammation is a defense reaction produced by the body to protect against pathogenic factors, whereas the persistent state of inflammation or excessive inflammatory response is the pathological basis of many afflictions. As the main type of activated inflammatory cells in the inflammatory environment, macrophages exert great influence on the outcome ...
Zhequan Fu +2 more
openaire +1 more source
PET Imaging Agents for Alzheimer’s Disease
2017In the past four decades, PET (positron emission tomography) imaging has been developed into a common diagnostic tool. After an i.v. injection of a small amount of radioactive probe, PET images are taken based on the decay of short-lived positron-emitting isotopes.
Seok Rye Choi +3 more
openaire +1 more source
Radiolabelling and evaluation of a novel sulfoxide as a PET imaging agent for tumor hypoxia
Nuclear Medicine and Biology, 2014[¹⁸F]FMISO is the most widely validated PET radiotracer for imaging hypoxic tissue. However, as a result of the pharmacokinetics of [¹⁸F]FMISO a 2h wait between tracer administration and patient scanning is required for optimal image acquisition. In order to develop hypoxia imaging agents with faster kinetics, we have synthesised and evaluated several ...
Evelyn, Laurens +9 more
openaire +2 more sources
Radiolabeled Nanohydroxyapatite as a Platform for the Development of New PET Imaging Agents
, 2018 Positron emission tomography (PET) imaging utilizes drugs labeled with positron emitters to target and evaluate different biological processes occurring in the body.
Queern, Stacy Lee
core +4 more sources
Radiolabelling and evaluation of novel haloethylsulfoxides as PET imaging agents for tumor hypoxia
Nuclear Medicine and Biology, 2012The significance of imaging hypoxia with the PET ligand [(18)F]FMISO has been demonstrated in a variety of cancers. However, the slow kinetics of [(18)F]FMISO require a 2-h delay between tracer administration and patient scanning. Labelled chloroethyl sulfoxides have shown faster kinetics and higher contrast than [(18)F]FMISO in a rat model of ischemic
Evelyn, Laurens +9 more
openaire +2 more sources
Synthesis and evaluation of 18F-labeled procainamide as a PET imaging agent for malignant melanoma
Bioorganic & Medicinal Chemistry Letters, 2023Malignant melanoma has an aggressive nature and a high metastatic propensity resulting in the highest mortality rate of any skin cancer. In this study, we synthesized 18F-labeled procainamide (PCA) for detection of melanoma using positron emission tomography (PET), and evaluated its biological characteristics.
Ayoung Pyo +5 more
openaire +2 more sources
Microwave Accelerated Synthesis of PET Image Contrast Agents for AD Research
Current Alzheimer Research, 2010Positron emission tomography (PET) imaging of Alzheimer's Disease (AD) offers the potential to provide early onset diagnosis and subsequent intervention, including guided treatment regimens. One of the restricting factors in clinical application of PET technology is the limited availability of radioligands with affinity to specific targets of interest.
A E, Kallmerten, G B, Jones
openaire +2 more sources
2019
Neuroinflammation is thought to play a key role in the development and progression of neurodegenerative diseases such as Alzheimer's disease. Positron emission tomography (PET) is an in vivo imaging technique capable of studying the biochemical processes which provide the molecular basis of disease.
Janssen, Bieneke, Mach, Robert H.
openaire +3 more sources
Neuroinflammation is thought to play a key role in the development and progression of neurodegenerative diseases such as Alzheimer's disease. Positron emission tomography (PET) is an in vivo imaging technique capable of studying the biochemical processes which provide the molecular basis of disease.
Janssen, Bieneke, Mach, Robert H.
openaire +3 more sources
Radiosynthesis of [18F]FPenM-C2Am: A PET Imaging Agent for Detecting Cell Death
2023Imaging agents capable of detecting the extent, timing, and distribution of tumor cell death following treatment could be used in clinical trials of novel cancer therapies to get an early indication of efficacy and subsequently in the clinic to guide treatment in individual patients.
Flaviu, Bulat +2 more
openaire +2 more sources