Results 91 to 100 of about 779,565 (306)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

PET Radioligands for in Vivo Visualization of Neuroinflammation. [PDF]

open access: yes, 2014
Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role in neurodegenerative disorders. The microglia which make up the innate immune system of the central nervous system are key cellular mediators of ...
Ory, Dieter   +4 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

A Conception of Moral Sensitivity and Everyday Consumption Practices: Insights from the Moralising Discourses of Pet Owners [PDF]

open access: yes, 2013
The marketing discipline is somewhat under-theorized regarding the moral meanings that both shape and are shaped by the everyday consumption practices of consumers.
McEachern, Morven   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

A construção social do mercado pet food no Brasil: estudo de caso da família Sens [PDF]

open access: yes, 2013
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Curso de Ciências Sociais.Esta pesquisa apresenta o estudo de caso da família Sens – proprietária de um Pet Shop.
Moura, Wandgleisom Garcia de
core  

PET-tutkimus syövän hoitovasteen seurannassa ja uusiutumisen toteamisessa [PDF]

open access: yes, 2022
FDG-PET-TT:llä saadaan yhdellä kuvauskerralla tieto syövän aiheuttamista anatomisista ja aineenvaihdunnallisista muutoksista. Suurin osa syövistä on metabolisesti aktiivisia.
Schildt Jukka   +2 more
core  

MODERN ISSUES OF ORGANIZING RADIO PHARM PREPARATIONS PRODUCTION BASED ON ⁶⁸GA

open access: yesРазработка и регистрация лекарственных средств, 2019
Functional diagnostics method (scintigraphy), connected with injection of radioactive isotopes with further getting of 2-D image by emitting radiation detection, is widely used in medicine.
O. A. Melnikova   +4 more
doaj  

People and Pets in the COVID-19 Pandemic and the Cost-of-Living Crisis: Identifying Trends in the Intake, Adoption and Return of Companion Animals During Times of Uncertainty

open access: yesAnimals
Pet ownership is the most common form of human–animal interaction (HAI), is prevalent worldwide and confers benefits for the health and wellbeing of humans.
Lindsay Murray   +2 more
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

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