Results 101 to 110 of about 756,186 (307)

Pet ownership and health [PDF]

This thesis presents three classes of mechanism that may explain reported associations between pet ownership and health benefits. The first suggests any association is noncausal.
McNicholas, June
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Is (18)F-FDG-PET suitable to predict clinical response to the treatment of geriatric depression? A systematic review of PET studies [PDF]

, 2016
BACKGROUND: Geriatric depression is one of the most common psychiatric disorders in later life. It differs from earlier depression in its presentation, etiology, risk factors, protective factors and outcome.
Ebmeier, K, Menghini, D, Janiri, L, Treglia, G, Ebmeier, Klaus, De Crescenzo, Franco, De Crescenzo, F, Ciliberto, M, Ciliberto, Mario, Treglia, Giorgio, Janiri, Luigi   +10 more
core   +1 more source

MODERN ISSUES OF ORGANIZING RADIO PHARM PREPARATIONS PRODUCTION BASED ON ⁶⁸GA

Разработка и регистрация лекарственных средств, 2019
Functional diagnostics method (scintigraphy), connected with injection of radioactive isotopes with further getting of 2-D image by emitting radiation detection, is widely used in medicine.
O. A. Melnikova, D. N. Muratov, A. F. Sitnikov, E. V. Shorikov, D. Yu. Kobesova   +4 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

D-mannose suppresses HIF-1α mediated metabolic reprogramming in clear cell renal cell carcinoma

Discover Oncology
The inactivation mutation of VHL drives the progression of clear cell renal cell carcinoma (ccRCC), while the deletion of VHL leads to the failure of HIF-1/2α to degrade normally through the ubiquitin proteasome pathway.
Ziyin Tian, Ruonan Zhang, Yan Ma, Jiaxi Li, Yunliang Li, Lei Lv   +5 more
doaj   +1 more source

People and Pets in the COVID-19 Pandemic and the Cost-of-Living Crisis: Identifying Trends in the Intake, Adoption and Return of Companion Animals During Times of Uncertainty

Animals
Pet ownership is the most common form of human–animal interaction (HAI), is prevalent worldwide and confers benefits for the health and wellbeing of humans.
Lindsay Murray, Janine Carroll, Jane Tyson   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A construção social do mercado pet food no Brasil: estudo de caso da família Sens [PDF]

, 2013
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Curso de Ciências Sociais.Esta pesquisa apresenta o estudo de caso da família Sens – proprietária de um Pet Shop.
Moura, Wandgleisom Garcia de
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source