Results 61 to 70 of about 589,422 (298)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

D-mannose suppresses HIF-1α mediated metabolic reprogramming in clear cell renal cell carcinoma

Discover Oncology
The inactivation mutation of VHL drives the progression of clear cell renal cell carcinoma (ccRCC), while the deletion of VHL leads to the failure of HIF-1/2α to degrade normally through the ubiquitin proteasome pathway.
Ziyin Tian, Ruonan Zhang, Yan Ma, Jiaxi Li, Yunliang Li, Lei Lv   +5 more
doaj   +1 more source

Perceptions among university students in Seville (Spain) of the rabbit as livestock and as a companion animal

World Rabbit Science, 2012
The rabbit has various utilities and roles, mainly as a meat-producing animal, game species, companion animal, laboratory animal or pest. Among these roles, rabbit breeding for meat has traditionally prevailed in the Mediterranean countries.
Pedro González-Redondo, Gema M. Contreras-Chacón   +1 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

D-mannose promotes the degradation of IDH2 through upregulation of RNF185 and suppresses breast cancer

Nutrition & Metabolism
Background D-mannose, an epimer of glucose, which is abundant in some fruits, such as cranberry, has been previously reported to inhibit urinary tract infection.
Ruonan Zhang, Ziyin Tian, Yanping Xu, Lei Lv   +3 more
doaj   +1 more source

Scabies Prevalence on Cats and Rabbits in Animal Hospital of East Java Livestock Service on 2021

Journal of Parasite Science
This study aims to obtain information and data on the prevalence of scabies in cats and rabbits at the Animal Hospital of East Java Livestock Service Surabaya.
Miladhiyah Nabila Ramadhanty, Kusnoto Kusnoto, Poedji Hastutiek, Mufasirin Mufasirin, Boedi Setiawan, Eka Pramyrtha Hestianah   +5 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Fluorinated phenylalanines: synthesis and pharmaceutical applications

Beilstein Journal of Organic Chemistry, 2020
Recent advances in the chemistry of peptides containing fluorinated phenylalanines (Phe) represents a hot topic in drug research over the last few decades.
Laila F. Awad, Mohammed Salah Ayoup
doaj   +1 more source

Serotonergic system in vivo with [11C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients [PDF]

, 2022
Elze R. Timmers, Débora Elisa Peretti, Marenka Smit, Bauke M. de Jong, Rudi Dierckx, Anouk Kuiper, Tom J. de Koning, David Vállez García, Marina A.J. Tijssen   +8 more
openalex   +1 more source