Results 71 to 80 of about 528,168 (327)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Imaging of atherosclerosis with [64Cu]Cu-DOTA-TATE in a translational head-to-head comparison study with [18F]FDG, and Na[18F]F in rabbits

Scientific Reports, 2023
Atherosclerosis is a chronic inflammatory disease of the larger arteries that may lead to cardiovascular events. Identification of patients at highest risk of cardiovascular events is challenging, but molecular imaging using positron emission tomography (
Constance E. Grandjean, Sune F. Pedersen, Camilla Christensen, Altea Dibenedetto, Thomas Eriksen, Tina Binderup, Andreas Kjaer   +6 more
doaj   +1 more source

Analysis procedure of the positronium lifetime spectra for the J-PET detector [PDF]

, 2017
Positron Annihilation Lifetime Spectroscopy (PALS) has shown to be a powerful tool to study the nanostructures of porous materials. Positron Emissions Tomography (PET) are devices allowing imaging of metabolic processes e.g. in human bodies.
Białas, Piotr, Curceanu, C., Czerwiński, Eryk, Dulski, Kamil, Gajos, Aleksander, Gorgol, M., Gupta-Sharma, Neha, Głowacz, Bartosz, Hiesmayr, B. C., Jasińska, B., Kisielewska, Daria, Korcyl, Grzegorz, Kowalski, P., Kozik, Tomasz, Krawczyk, Nikodem, Krzemień, Wojciech, Kubicz, Ewelina, Mohammed, Muhsin, Moskal, Paweł, Niedźwiecki, Szymon, Pawlik-Niedźwiecka, Monika, Pałka, Marek, Raczyński, L., Raj, Juhi, Rudy, Zbigniew, Sharma, Sushil, Shivani, Shivani, Shopa, R. Y., Silarski, Michał, Skurzok, Magdalena, Wieczorek, Anna, Wiślicki, W., Zgardzińska, B., Zieliński, Marcin   +33 more
core   +2 more sources

Design of a generic method for single dual-tracer PET imaging acquisition in clinical routine [PDF]

, 2023
Nasrin Taheri, B. Le Crom, Caroline Bouillot, Michel Chérel, Nicolas Costes, Sébastien Gouard, Séverine Marionneau‐Lambot, T. Merlin, Dimitris Visvikis, Simon Stute, Thomas Carlier   +10 more
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease

NeuroImage: Clinical, 2019
Although experimental studies have shown that global cerebral hypoperfusion leads to amyloid deposition in the hemisphere with carotid artery occlusion in rodents, the results of such occurrence are controversial in humans.
Hiroshi Yamauchi, Shinya Kagawa, Masaaki Takahashi, Naoya Oishi, Masahiro Ono, Tatsuya Higashi   +5 more
doaj   +1 more source

A glance at imaging bladder cancer. [PDF]

, 2018
Purpose: Early and accurate diagnosis of Bladder cancer (BCa) will contribute extensively to the management of the disease. The purpose of this review was to briefly describe the conventional imaging methods and other novel imaging modalities used for ...
Halpern, Ethan J., Kim, Sung, Salmanoglu, Ebru, Thakur, Mathew L., Trabulsi, Edouard J.   +4 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source