Results 71 to 80 of about 515,617 (283)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis. [PDF]

, 2018
Radiomics is an emerging technology for imaging biomarker discovery and disease-specific personalized treatment management. This paper aims to determine the benefit of using multi-modality radiomics data from PET and MR images in the characterization ...
Arasu, Vignesh A, Behr, Spencer C, Copeland, Timothy P, Esserman, Laura, Franc, Benjamin L, Harnish, Roy J, Huang, Shih-Ying, Hylton, Nola M, Jones, Ella F, Kornak, John, Liu, Gengbo, Mitra, Debasis, Price, Elissa R, Seo, Youngho   +13 more
core  

Analysis procedure of the positronium lifetime spectra for the J-PET detector [PDF]

, 2017
Positron Annihilation Lifetime Spectroscopy (PALS) has shown to be a powerful tool to study the nanostructures of porous materials. Positron Emissions Tomography (PET) are devices allowing imaging of metabolic processes e.g. in human bodies.
Białas, Piotr, Curceanu, C., Czerwiński, Eryk, Dulski, Kamil, Gajos, Aleksander, Gorgol, M., Gupta-Sharma, Neha, Głowacz, Bartosz, Hiesmayr, B. C., Jasińska, B., Kisielewska, Daria, Korcyl, Grzegorz, Kowalski, P., Kozik, Tomasz, Krawczyk, Nikodem, Krzemień, Wojciech, Kubicz, Ewelina, Mohammed, Muhsin, Moskal, Paweł, Niedźwiecki, Szymon, Pawlik-Niedźwiecka, Monika, Pałka, Marek, Raczyński, L., Raj, Juhi, Rudy, Zbigniew, Sharma, Sushil, Shivani, Shivani, Shopa, R. Y., Silarski, Michał, Skurzok, Magdalena, Wieczorek, Anna, Wiślicki, W., Zgardzińska, B., Zieliński, Marcin   +33 more
core   +2 more sources

PET/MRI in Endometrial Cancer: Imaging Biomarkers are Associated with Disease Progression and Overall Survival [PDF]

, 2023
I‐Lun Shih, Ruoh‐Fang Yen, Chi‐An Chen, Wen‐Fang Cheng, Bang‐Bin Chen, Quan-Yin Zheng, Mei‐Fang Cheng, Jenny Ling‐Yu Chen, Tiffany Ting‐Fang Shih   +8 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation [PDF]

, 2013
New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated.
Carlin, Stephen M., Hooker, Jacob M, Kamlet, Adam, Lee, Eunsung, Moseley, Christian K., Neumann, Constanze Nicole, Ritter, Tobias, Stephenson, Nickeisha A   +7 more
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan

Journal of Biomedical Physics and Engineering, 2019
Background: Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has acquired the first smallest footprint of BG-75 Generator for 18FDG-based PET/CT clinical imaging.
Zaman M. U., Fatima N., Mehdi S. U., Sami M., Khan Kh., Khan G.   +5 more
doaj  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Studies of discrete symmetries in decays of positronium atoms [PDF]

, 2018
A positronium - a bound state of electron and positron - is an eigenstate of parity and charge conjugation operators which decays into photons. It is a unique laboratory to study discrete symmetries whose precision is limited, in principle, by the ...
Curceanu, Catalina, Czerwiński, Eryk, Dulski, Kamil, Gajos, Aleksander, Gorgol, Marek, Heczko, Andrzej, Hiesmayr, Beatrix C., Jasińska, Bożena, Kisielewska, Daria, Korcyl, Grzegorz, Korzeniak, Bartłomiej, Kowalski, Paweł, Kozik, Tomasz, Krzemień, Wojciech, Kubicz, Ewelina, Migdał, Wojciech, Mohammed, Muhsin, Moskal, Paweł, Niedźwiecki, Szymon, Pawlik-Niedźwiecka, Monika, Pałka, Marek, Raczyński, Lech, Raj, Juhi, Rudy, Zbigniew, Sharma, Sushil, Shivani, Shivani, Shopa, Roman Y., Silarski, Michał, Skurzok, Magdalena, Wiślicki, Wojciech, Zgardzińska, Bożena, Zieliński, Marcin   +31 more
core   +1 more source