Results 81 to 90 of about 10,344 (216)

Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 895-913, March 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancers, typically diagnosed at an advanced stage due to its subtle and often absent early symptoms. Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer‐related deaths by 2030.
Muhammad Masroor Hussain, Sana Qammar, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source

Was Motorized Spiral Enteroscopy Too Risky? A Systematic Review and Meta‐Analysis Including German Registry Data

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background and Study Aims Motorized spiral enteroscopy (MSE) was introduced as a major advancement in small‐bowel enteroscopy, enabling higher complete enteroscopy rates with shorter procedure times. However, after a fatal adverse event (AE) involving severe esophageal injury, the device was withdrawn from the market in July 2023.
Ingo Steinbrück, Armin Kuellmer, Siegbert Faiss, Hendrik Buchholz, Björn Lewerenz, Daniel Fitting, Felix Wiedbrauck, Stephan Hollerbach, Arthur Schmidt, Johannes Wilhelm Rey, Martha M. Kirstein, Franz‐Ludwig Dumoulin, Fabian Maximilian Wittich, Andreas Wannhoff, Jürgen Pohl, Matthias Friesicke, Viktor Rempel, Hans‐Peter Allgaier, Christian Wiessner, Thomas Rösch   +19 more
wiley   +1 more source

Computer-Assisted Segmentation of Videocapsule Images Using Alpha-Divergence-Based Active Contour in the Framework of Intestinal Pathologies Detection [PDF]

, 2014
Visualization of the entire length of the gastrointestinal tract through natural orifices is a challenge for endoscopists. Videoendoscopy is currently the “gold standard” technique for diagnosis of different pathologies of the intestinal tract.
Dray, X., Granado, B., Histace, A., Matuszewski, Bogdan, Meziou, L., Precioso, F., Romain, O.   +6 more
core   +6 more sources

LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes [PDF]

, 2017
Germline mutations of the LKB1 (STK11) tumor suppressor gene lead to Peutz-Jeghers syndrome (PJS) and predisposition to cancer. LKB1 encodes a serine/threonine kinase generally inactivated in PJS patients.
Antonarakis, Stylianos E., Buchet-Poyau, Karine, Collart, Martine A., Lin-Marq, Nathalie, Mehenni, Hamid, Picard, Didier, Reymond, Alexandre   +6 more
core  

Advances in non‐germ cell tumours of the testis: focus on new molecular developments in sex cord‐stromal tumours

Histopathology, Volume 88, Issue 1, Page 230-251, January 2026.
In this review, we summarise the major recent advances in Testicular Sex Cord‐Stromal Tumours, focusing on molecular alterations and biomarkers relevant for diagnosis, classification and prognosis. Testicular sex cord‐stromal tumours (TSCSTs) represent ~4%–8% of all testicular neoplasms.
João Lobo, Andres M Acosta
wiley   +1 more source

Peutz-Jeghers syndrome: presentation of a patient and literature review

Zdravniški Vestnik, 2009
Introduction: Colorectal cancer carcinogenesis is a complex, long-lasting multistep process. Patients with diff erent polyposis syndromes, including Peutz-Jeghers, have signifi cantly increased risk for diff erent types of cancer.Patients and methods: In
Pavel Skok, Andreja Ocepek, Ekaterina Genslitakaya, Rajko Kavalar   +3 more
doaj  

Peutz-Jeghers Syndrome: In Siblings with Palmer-Plantar Pigmentation

Journal of Indian Academy of Oral Medicine and Radiology, 2011
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by typical pigmented perioral maculesn pigmented spots in the oral mucosa and digits along with hamartomatous polyps in the gastrointestinal tract.
K V Suresh, Prashanth Shenai, Laxmikanth Chatra   +2 more
doaj   +1 more source

Peutz-Jeghers LKB1 mutants fail to activate GSK-3β, preventing it from inhibiting Wnt signaling [PDF]

, 2018
Peutz-Jeghers syndrome (PJS) is caused by germline mutations in the LKB1 gene, which encodes a serine-threonine kinase that regulates cell proliferation and polarity. This autosomal dominant disorder is characterized by mucocutaneous melanin pigmentation,
Antonarakis, Stylianos, Borel, Christelle, Lin-Marq, Nathalie   +2 more
core  

Virilizing Leydig-Sertoli cell ovarian tumor associated with endometrioid carcinoma of the endometrium in a postmenopausal patient: Case report and general considerations [PDF]

, 2012
Sertoli-Leydig cell tumors (SLCTs) are rare tumors mostly occurring in young women. Here we report an unusual case of a SLCT with simultaneous occurrence of endometrioid adenocarcinoma of the endometrium in a woman in ...
Autore, C, Chioma, L, Cicerone, E, Di Giacinto, P, Fabbri, A, Gnessi, L, Guccione, L, Mariani, S, Moretti, C, Ulisse, S, Vancieri, G   +10 more
core   +2 more sources

Ligand‐Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide‐Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Rumman Reza, Md. Nazmus Samdani, Niaz Morshed, Raihana Haque Jebin, Imtiaz Ahmed, Md. Selim Reza, Harleen Khatra   +6 more
wiley   +1 more source