Results 91 to 100 of about 337 (145)

Activation of hippocampal microglia in a murine model of cancer-induced pain

Journal of Pain Research, 2019
Tanya Miladinovic,1,2 Manu Sharma,1,2 Andy Phan,1,2 Hana Geres,1,2 Robert G Ungard,1,2 Katja Linher-Melville,1,2 Gurmit Singh1,2 1Michael G. DeGroote Institute for Pain Research and Care, Medicine, McMaster University, Hamilton, ON L8S 4M1, Canada ...
Miladinovic T, Sharma M, Phan A, Geres H, Ungard RG, Linher-Melville K, Singh G   +6 more
doaj  

Macrophages as Potential Therapeutic Targets in Acute Myeloid Leukemia

Biomedicines
Acute myeloid leukemia (AML) is a heterogenous malignant hemopathy, and although new drugs have emerged recently, current treatment options still show limited efficacy.
Oana Mesaros, Madalina Onciul, Emilia Matei, Corina Joldes, Laura Jimbu, Alexandra Neaga, Oana Serban, Mihnea Zdrenghea, Ana Maria Nanut   +8 more
doaj   +1 more source

Supplementary_Tables – Supplemental material for Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors

, 2019
Supplemental material, Supplementary_Tables for Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors by Robert Wesolowski, Neelesh Sharma, Laura Reebel, Mary Beth Rodal ...
Robert Wesolowski (6868577), Afshin Dowlati (627046), Laura Reebel (6868580), Paul Severson (6868589), Brian L. West (613090), Alexandra Peck (490619), Mai H. Le (6868595), Hope S. Rugo (817500), David A. Karlin (6868592), Neelesh Sharma (602264), Lisa M. Coussens (2641957), Adhirai Marimuthu (6868586), Mary Beth Rodal (6868583)   +12 more
core   +1 more source

Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma

Bone Research
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonunion. The impact of MTI on the inflammatory response to fracture and on the immunomodulation of skeletal stem/progenitor cells (SSPCs)
Yasmine Hachemi, Simon Perrin, Maria Ethel, Anais Julien, Julia Vettese, Blandine Geisler, Christian Göritz, Céline Colnot   +7 more
doaj   +1 more source

Supplementary_Figure_1 – Supplemental material for Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors

, 2019
Supplemental material, Supplementary_Figure_1 for Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors by Robert Wesolowski, Neelesh Sharma, Laura Reebel, Mary Beth Rodal ...
Robert Wesolowski (6868577), Afshin Dowlati (627046), Laura Reebel (6868580), Paul Severson (6868589), Brian L. West (613090), Alexandra Peck (490619), Mai H. Le (6868595), Hope S. Rugo (817500), David A. Karlin (6868592), Neelesh Sharma (602264), Lisa M. Coussens (2641957), Adhirai Marimuthu (6868586), Mary Beth Rodal (6868583)   +12 more
core   +1 more source

Macrophage polarization in hematologic cancers: mechanisms and therapeutic strategies

Blood Research
Leukemia treatment faces persistent challenges, including chemotherapy resistance and relapse, highlighting macrophage polarization in the tumor microenvironment (TME) as a therapeutic target.
Zhi-gang Chen, Huan Yang, Chao Yang, Yu-tong Xie, Chen-mo Li, Tong Xiao, Jun-hong Wu, Ming-Yang Gao, Cong-cong Wang, Yu-le Zhao, Jia Liu, Lei Gao   +11 more
doaj   +1 more source

Phase 1b/2 study of orally administered pexidartinib in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma

BACKGROUND: Glioblastoma (GBM) has a median survival of(PLX3397) is a small-molecule inhibitor of CSF1R, KIT, and oncogenic FTL3, which are implicated in GBM treatment resistance.
Iwamoto, Fabio, Pelayo, Michael, Cohen, Adam L, Mrugala, Maciej M, Colman, Howard, Hsu, Henry H, Ligon, Keith L, Raizer, Jeffrey, Mendez, Joe S, Hutchinson, Marguerite, Reardon, David A, West, Brian L, Eckenstein, Midori, Sterba, Michael, Wong, Eric T, Puduvalli, Vinay K, Plotkin, Scott R, Zhang, Chao, Jensen, Randy L, Burt, Lindsay M, Salzman, Karen L, Chamberlain, Marc, Walbert, Tobias   +22 more
core   +1 more source

Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver

Journal of Pharmaceutical and Biomedical Analysis
Pexidartinib (PEX, TURALIO®), a tyrosine kinase inhibitor, is approved for treating tenosynovial giant cell tumor in adults. However, its potential to cause fatal liver injury has prompted the U.S. FDA to issue a black box warning, and the mechanisms underlying its hepatotoxicity remain largely unknown.
Xuan Qin, Si Chen, John M. Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R. MacKenzie, Feng Li   +8 more
openaire   +2 more sources

Metadata supporting data files on "A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel"

, 2019
This data record describes the data files that support the findings of the related publication: A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel.Study design summary/description methodology: This ...
A. Jo Chien (6679492), Colby Hyland (6679459), Hope S. Rugo (6679489), Sorbarikor Piawah (3337713), Sarah E. Umetsu (6679487), Laura J. Esserman (477509)   +5 more
core   +1 more source

Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors

Frontiers in Immunology
IntroductionMalignant peripheral nerve sheath tumors (MPNST) pose a significant therapeutic challenge due to high recurrence rates after surgical resection and a largely ineffective response to traditional chemotherapy.
Siddhi N. Paudel, Brian J. Hutzen, Katherine E. Miller, Katherine E. Miller, Elizabeth A. R. Garfinkle, Chun-Yu Chen, Pin-Yi Wang, Andrea M. Glaspell, Mark A. Currier, Emily M. Ringwalt, Louis Boon, Elaine R. Mardis, Elaine R. Mardis, Mitchell S. Cairo, Nancy Ratner, Rebecca D. Dodd, Kevin A. Cassady, Kevin A. Cassady, Timothy P. Cripe, Timothy P. Cripe, Timothy P. Cripe   +20 more
doaj   +1 more source