Results 81 to 90 of about 337 (145)

Is the Relationship Between Adolescent Social Isolation and Anxiety‐Like Behaviors Altered by Microglia Ablation in Female Long Evans Rats?

Brain and Behavior
Objective Despite extensive, cross‐disciplinary research revealing a relationship between early life stress (ELS) and an increased risk for neuropsychiatric disorders, the underlying processes mediating this relationship are not fully understood. Further,
Matthew A. Blumberg, Ava Shipman, Lidia Olyha, Stephen C. Gironda, Jeffrey L. Weiner   +4 more
doaj   +1 more source

Pexidartinib and CSF1R Inhibitors as Treatment for Tenosynovial Giant Cell Tumors [PDF]

Oncology & Hematology Review (US), 2021
Jonathan C Trent, Sheila A Conway, Erika Garbrecht, Emily Jonczak, Gina D'Amato, Ty Subhawong, Caroline J Granger   +6 more
openaire   +1 more source

Pexidartinib and standard neoadjuvant therapy in the adaptively randomized I-SPY2 trial for early breast cancer. [PDF]

PURPOSE: We investigated the small-molecule receptor tyrosine kinase-inhibitor of colony-stimulating factor-1 receptor pexidartinib in the stage II/III breast cancer in the I-SPY2 platform trial.
Steeg, Katherine, Wilson, Amy, Rugo, Hope S, DeMichele, Angela M, Matthews, Jeffrey, Van\u27t Veer, Laura J, Hylton, Nola M, Asare, Smita, Asare, Smita M, Wallace, Anne, Berry, Donald A, Vant Veer, Laura, Han, Hyo, Berry, Donald, Esserman, Laura J, Perlmutter, Jane, Clennell, Julia L, Boughey, Judy, Buxton, Meredith, DeMichele, Angela, Singhrao, Ruby, Yee, Douglas, Boughey, Judy C, Matthews, Jeffrey B, Clennell, Julia, Isaacs, Claudine, Rugo, Hope, Fraser Symmans, W, Yau, Christina, Campbell, Mike, Wallace, Anne M, Hylton, Nola, Han, Hyo S, Jo Chien, A, Esserman, Laura   +34 more
core   +1 more source

Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer

Genes and Diseases
Ovarian cancer is the tumor with the highest mortality among gynecological malignancies. Studies have confirmed that paclitaxel chemoresistance is associated with increased infiltration of tumor-associated macrophages (TAMs) in the microenvironment ...
Meijia Yu, Yiming Wu, Qingfang Li, Weiqi Hong, Yang Yang, Xiaoyi Hu, Yanfei Yang, Tianqi Lu, Xia Zhao, Xiawei Wei   +9 more
doaj   +1 more source

Sexually dimorphic effects of pexidartinib on nerve injury‐induced neuropathic pain in mice

Glia
Abstract It is well‐established that spinal microglia and peripheral macrophages play critical roles in the etiology of neuropathic pain; however, growing evidence suggests sex differences in pain hypersensitivity owing to microglia and macrophages.
Fumihiro Saika, Yohji Fukazawa, Yu Hatano, Shiroh Kishioka, Yuko Hino, Shinjiro Hino, Kentaro Suzuki, Norikazu Kiguchi   +7 more
openaire   +2 more sources

Patient-derived organoid xenografts model esophageal cancer cachexia and enable assessment of anti-inflammatory drug repositioning

iScience
Summary: Esophageal squamous cell carcinoma (ESCC) is highly associated with cancer cachexia, a wasting syndrome lacking effective treatments. Existing animal models fail to capture key clinical and biological features of this condition.
Bryan Chee-chad Lung, Alvin Ka-kiu Leung, Carissa Wing-Yan Wong, Ian Yu-hong Wong, Cheryl Chee Heng Lung, Anthony Wing-ip Lo, Josephine Mun-Yee Ko, Wei Dai, Dora Lai-wan Kwong, Simon Law, Maria Li Lung, Valen Zhuoyou Yu   +11 more
doaj   +1 more source

Pexidartinib: Current advances in the symptomatic treatment of tenosynovial giant cell tumors

Cancer and Metastasis Reviews
Abstract Tenosynovial giant cell tumors (TGCTs), a rare benign mesenchymal neoplasm of synovial tissue, often incurs chronic pain, joint destruction and repeated surgery, markedly impairing quality of life. Historically, surgery was the only effective option.
Yuan, Yulin, Zhang, Zhuoer, Jiang, Yanfeng, Ye, Ting, Chen, Jing   +4 more
openaire   +1 more source

Real-world experience of patients newly initiated on pexidartinib for tenosynovial giant cell tumor

Future Oncology
Tenosynovial giant-cell tumor (TGCT) is a rare condition characterized by pain, stiffness, and limited range of motion. Pexidartinib is the first regulatory-approved systemic therapy for adult patients with symptomatic TGCT not amenable for surgery. This study evaluated symptom improvement in patients who newly initiated pexidartinib.A longitudinal ...
Dong Dai, Kristen Tecson, Irene Pan, Xin Ye, William Tap   +4 more
openaire   +3 more sources

The CSF-1R inhibitor pexidartinib affects FLT3-dependent DC differentiation and may antagonize durvalumab effect in patients with advanced cancers

International audienceTumor-associated macrophages (TAMs) are a critical determinant of resistance to PD-1/PD-L1 blockade. This phase 1 study (MEDIPLEX, NCT02777710) investigated the safety and efficacy of pexidartinib, a CSF-1R–directed tyrosine kinase ...
Korakis, Iphigénie, Dubois, Bertrand, Nkodia, Axelle, Rodriguez, Céline, Menetrier-Caux, Christine, Bendriss-Vermare, Nathalie, Voissière, Aurélien, Pérol, David, Berthet, Justine, Chabaud, Sylvie, Garin, Gwenaelle, Caux, Christophe, Delord, Jean-Pierre, Terret, Catherine, Montane, Laure, Eberst, Lauriane, Cassier, Philippe, Bidaux, Anne-Sophie, Gomez-Roca, Carlos, Treilleux, Isabelle   +19 more
core   +1 more source

Phase 1/2a study of double immune suppression blockade by combining a CSF1R inhibitor (pexidartinib/PLX3397) with an anti PD-1 antibody (pembrolizumab) to treat advanced melanoma and other solid tumors.

, 2016
TPS465 Background: Tumor-associated macrophages (TAMs) support tumor growth and cause tumor resistance to chemotherapy and radiation therapy; myeloid-derived suppressor cells (MDSCs) suppress anti-tumor immunity and cause resistance to PD-1 inhibition.
Marguerite Hutchinson, Peter D. Eisenberg, David Ross Kaufman, Siwen Hu-Lieskovan, Amy M. Weise, Ireene Aromin, Amita Patnaik, Zev A. Wainberg, Jasgit C. Sachdev, Sandra Tong   +9 more
core   +1 more source