Results 91 to 100 of about 6,004 (229)

The complement system: A key player in the host response to infections

European Journal of Immunology, Volume 54, Issue 11, November 2024.
Duality of the complement system during infection: An adequate immune defense clears the infection and restores tissue resilience, whereas a maladaptive response due to complement hyperactivation results in hyperinflammation and tissue injury, as seen in sepsis and pneumonia.
Archana Jayaraman, Sarah Walachowski, Markus Bosmann   +2 more
wiley   +1 more source

Stellabody: A novel hexamer‐promoting mutation for improved IgG potency

Immunological Reviews, Volume 328, Issue 1, Page 438-455, November 2024.
Summary Advances in antibody engineering are being directed at the development of next generation immunotherapeutics with improved potency. Hexamerisation of IgG is a normal physiological aspect of IgG biology and recently described mutations that facilitate this process have a substantial impact upon monoclonal antibody behavior resulting in the ...
Clarissa A. Whitehead, Bruce D. Wines, Anna M. Davies, James M. McDonnell, Halina M. Trist, Sandra E. Esparon, P. Mark Hogarth   +6 more
wiley   +1 more source

A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

Cell Reports, 2018
Summary: Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparum during blood stage infection.
Gigliola Zanghì, Shruthi S. Vembar, Sebastian Baumgarten, Shuai Ding, Julien Guizetti, Jessica M. Bryant, Denise Mattei, Anja T.R. Jensen, Laurent Rénia, Yun Shan Goh, Robert Sauerwein, Cornelus C. Hermsen, Jean-François Franetich, Mallaury Bordessoulles, Olivier Silvie, Valérie Soulard, Olivier Scatton, Patty Chen, Salah Mecheri, Dominique Mazier, Artur Scherf   +20 more
doaj   +1 more source

Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases

Journal of Extracellular Vesicles, Volume 13, Issue 8, August 2024.
Abstract Parasitic diseases have a significant impact on human and animal health, representing a major hazard to the public and causing economic and health damage worldwide. Extracellular vesicles (EVs) have long been recognized as diagnostic and therapeutic tools but are now also known to be implicated in the natural history of parasitic diseases and ...
Ana Acacia Sá Pinheiro, Ana Claudia Torrecilhas, Bruno Solano de Freitas Souza, Fernanda Ferreira Cruz, Herbert Leonel de Matos Guedes, Tadeu Diniz Ramos, Miqueias Lopes‐Pacheco, Celso Caruso‐Neves, Patricia R. M. Rocco   +8 more
wiley   +1 more source

Characterization of a Pfemp1 variant from a P. falciparum field is isolate and the development of anti-Pfemp1 antibodies [PDF]

, 2014
Rosetting (binding of infected erythrocytes to uninfected ones) is a parasite adhesion phenotype thought to be mediated by Plasmodium falciparum membrane protein 1 (PfEMP1). Despite the association between rosetting and severe malaria in Africa, rosette-mediating PfEMP1 variants from African-derived strains are yet to be characterized.
openaire   +1 more source

Die biochemische Analyse des Plasmodium falciparum Zytoadhärenz Moleküls PfEmp1 zeigt einen potentiell neuen Mechanismus für die Insertion von Oberflächenproteinen in Membranen [PDF]

, 2004
Das 1995 entdeckte Plasmodium falciparum Zytoadhärenz-Molekül PfEmp1 wird auf der Oberfläche von infizierten Erythrozyten exponiert und ist ein wichtiger Pathogenitätsfaktor in Malaria.
Lingelbach, Klaus (Prof. Dr.), Papakrivos, Janni   +1 more
core   +1 more source

Natural killer cell antibody‐dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission

Clinical &Translational Immunology, Volume 13, Issue 11, 2024.
Natural killer (NK) cells make important contributions to anti‐malarial immunity through antibody‐dependent cellular cytotoxicity (ADCC), but the role of different components of this pathway in promoting NK cell activation remains unclear. We compared the functions and phenotypes of NK cells from malaria‐exposed and malaria‐naive donors, and then ...
Stephen Tukwasibwe, Savannah Nicole Lewis, Yoweri Taremwa, Kattria van der Ploeg, Kathleen D Press, Maureen Ty, Felistas Namirimu Nankya, Kenneth Musinguzi, Evelyn Nansubuga, Florian Bach, Martin Chamai, Martin Okitwi, Gerald Tumusiime, Annettee Nakimuli, Francesco Colucci, Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, Bryan Greenhouse, Grant Dorsey, Philip J Rosenthal, Isaac Ssewanyana, Prasanna Jagannathan   +22 more
wiley   +1 more source

Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes [PDF]

, 2012
BACKGROUND: The ability of Plasmodium falciparum to undergo antigenic variation, by switching expression among protein variants encoded by multigene families, such as var, rif and stevor, is key to the survival of this parasite in the human host.
Bismarck Dinko, Christian W Wang, Colin J Sutherland, David E Arnot, Dominique C Bengtsson, John P Lusingu, Louise Turner, Mwakalinga, Steven B, Steven B Mwakalinga, Thomas Lavstsen, Thor G Theander   +10 more
core   +2 more sources

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

WIREs RNA, Volume 15, Issue 1, January/February 2024.
LncRNAs derived from Exosome facilitate the interaction between hosts and parasites, impacting normal physiology or pathology in malaria‐infected individuals. Abstract Overcoming challenges associated with malaria eradication proves to be a formidable task due to the complicated life cycle exhibited by the malaria parasite and the lack of safe and ...
Jin‐guang Chen, Shuang‐chun Liu, Qing Nie, Yun‐ting Du, Yin‐yi Lv, Lian‐ping He, Guang Chen   +6 more
wiley   +1 more source

Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

BMC Medicine, 2017
Background Expression of group A and the A-like subset of group B Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM). The diversity of var sequences combined with the challenges of distinct classification
Estela Shabani, Benjamin Hanisch, Robert O. Opoka, Thomas Lavstsen, Chandy C. John   +4 more
doaj   +1 more source