Results 81 to 90 of about 6,004 (229)
Investigating the Host Binding Signature on the Plasmodium falciparum PfEMP1 Protein Family
PLoS Pathogens, 2011 The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family plays a central role in antigenic variation and cytoadhesion of P. falciparum infected erythrocytes. PfEMP1 proteins/var genes are classified into three main subfamilies (UpsA, UpsB, and UpsC) that are hypothesized to have different roles in binding and disease.
Joel H. Janes +7 more
openalex +6 more sources
Haplotypes of the Endothelial Protein C Receptor (EPCR) Gene are Not Associated with Severe Malaria in Tanzania. [PDF]
, 2015 Endothelial protein C receptor (EPCR) was recently identified as a key receptor for Plasmodium falciparum erythrocyte membrane protein 1 mediating sequestration of P. falciparum-infected erythrocytes in patients suffering from severe malaria.
Alifrangis, Michael +11 more
core +2 more sources
Severe malaria: what's new on the pathogenesis front? [PDF]
, 2016 Plasmodium falciparum causes the most severe and fatal form of malaria in humans with over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of severe falciparum malaria, is often fatal and represents a major public ...
Grau, Georges Emile Raymond +1 more
core +1 more source
Antithrombotic but not anticoagulant activity of the thrombin‐binding RNA aptamer Apta‐1
British Journal of Pharmacology, Volume 182, Issue 6, Page 1358-1376, March 2025.Background and Purpose Pharmacological intervention of thrombosis is challenging, requiring a fined tune balance between beneficial antithrombotic effect versus risk of major bleeding complications. In this investigation, we elucidated the antithrombotic capacity of the novel 90‐mer RNA aptamer Apta‐1 and its underlying mechanism of action ...
Luiza Jedlina +9 more
wiley +1 more source
PLoS ONE, 2011 BackgroundRosetting is a Plasmodium falciparum virulence factor implicated in the pathogenesis of life-threatening malaria. Rosetting occurs when parasite-derived P.
Ashfaq Ghumra +6 more
doaj +1 more source
Different aspects of emotional processes in apathy: Application of the French translated dimensional apathy scale [PDF]
, 2018 Apathy is a behavioural symptom that occurs in neuropsychiatric, neurological and neurodegenerative disease. It is defined as a lack of motivation and/or a quantitative reduction of goal-directed behaviour. Levy and Dubois Cerebral Cortex, 16(7), 916–928
A Arnould +49 more
core +2 more sources
Journal of Immunology Research, Volume 2025, Issue 1, 2025.Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria‐infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injury pathways have been
Lívia Rosa-Fernandes +9 more
wiley +1 more source
Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C. [PDF]
PLoS ONE, 2014 Sickle hemoglobin (Hb) S and HbC may protect against malaria by reducing the expression of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of parasitized red blood cells (RBCs), thereby weakening their cytoadherence to ...
Jeanette T Beaudry +7 more
doaj +1 more source
Molecular Microbiology, Volume 122, Issue 6, Page 948-967, December 2024.Cytoadhesion of P. falciparum‐infected red blood cells to endothelial cells leads to significant upregulation of genes associated with immune response, nucleosome assembly, NF‐kappa B signaling, and angiogenesis in these cells. Increasing the temperature to 40°C (fever) led to further upregulation of many genes, particularly those involved in cytokine ...
Johannes Allweier +7 more
wiley +1 more source
Expansion of Lysine-rich repeats in Plasmodium proteins generates novel localisation sequences that target the periphery of the host Erythrocyte [PDF]
, 2016 Repetitive low-complexity sequences, mostly assumed to have no function, are common in proteins that are exported by the malaria parasite into its host erythrocyte.
Davies, Heledd +2 more
core +1 more source