Results 141 to 150 of about 5,754 (180)

PGT-M for Couples with a Single-Gene Disorder

2020
For all patients considering fertility, a detailed family history should be ascertained from the patient and partner (if there is a partner). Ideally, this would be a full pedigree of family members up to three generations from the individual. This entails getting the medical history of parents and sibs (first degree); aunts, uncles, and grandparents ...
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69. IMPROVED IVF SUCCESS OF COMBINED PGT-M AND PGT-A APPLICATIONS

Reproductive BioMedicine Online, 2019
Introduction Preimplantation Genetic Testing (PGT) has been performed since 1989 and utilized in the diagnosis of all genetic conditions at preimplantation stage ( 1 ). In the previous years, only a disorder could be diagnosed with the use of multiplex nested PCR in PGT applications.
E. Unsal, S. Aktuna, M. Aydin, L. Ozer, V. Baltacı   +4 more
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P-567 Cycle outcomes using Haploseek combining PGT-M and PGT-A compared to PGT-M only in patients tested for monogenic diseases

Human Reproduction
Abstract Study question Is there a difference in cycle outcomes when embryos are tested solely for monogenic diseases (PGT-M) or a combination of PGT-M and chromosomal abnormalities (PGT-A)? Summary answer The Haploseek combining PGT ...
M Youngster, N Sharon, I Granot, A Kedem, E Aizenman Fridman, P Renbaum, D Zeevi, M Baum, G Altarescu, E Maman, A Hourvitz   +10 more
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49. Molecular PGT-M for VUS in the genomic era: to do or not to do?

Reproductive BioMedicine Online, 2019
Introduction The new chromosomal microarray CMA technology, allows the identification of genetic defects in many disorders that would previously have escaped detection. Alongside the benefits, it exposes us to copy number variants (CNV) whose pathogenic significance is unclear "Variants of unknown significance" (VUS).
K. Rotshenker Olshinka, O. Weiss, N. Srebnik, S. Shaviv, O. Freireich, R. Segel, T. Eldar Geva, G. Altarescu   +7 more
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A Qualitative Exploration of Oncology Clinician’s Needs for PGT-M Discussions in Clinical Practice

Journal of Adolescent and Young Adult Oncology
Purpose: Oncology clinicians are appropriately positioned to facilitate discussions of assisted reproductive technologies including preimplantation genetic testing for monogenic disease (PGT-M), in the context of cancer treatment or surveillance.
Davia A. Schioppo, Jessica P.H. Greenwood, Kristen A. Miller, Hetal S. Vig   +3 more
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Strategies and Indications for Preimplantation Genetic Testing for Monogenic Disorders (PGT-M)

2020
Preimplantation genetic testing for monogenic disorders (PGT-M) is now an established clinical procedure performed for some indications that have never been considered for prenatal diagnosis, such as common late-onset disorders or preimplantation HLA typing.
Anver Kuliev, Svetlana Rechitsky, Joe Leigh Simpson   +2 more
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Good laboratory practice for PGT-M: Turkish Society of Reproductive Medicine guidelines

Reproductive BioMedicine Online
This guideline was prepared by the Turkish Society of Reproductive Medicine to define the conditions and requirements for an outsourced preimplantation genetic testing (PGT) programme in line with the experience and needs of practitioners. This guideline is intended to be a reference document for assisted reproductive technology centres, genetic ...
Evrim Unsal, Suleyman Aktuna, Berna Arda, Basak Balaban, Volkan Baltaci, Asina Bayram, Gurkan Bozdag, Zafer Nihat Candan, Murat Cetinkaya, Serdar Ceylaner, Necati Findikli, Hale Goksever Celik, Cihan Halicigil, Semra Kahraman, Metin Kayacaglayan, Ipek Keles, Ayse Kurtoglu, Aylin Mutlu, Gulay Ozgon, Yavuz Emre Sukur, Mehmet Ali Tufekci, Kayhan Yakin, Hakan Yelke, Sule Yildiz, Baris Ata   +24 more
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PGT-M FOR DE NOVO VARIANTS: DELETION BREAKPOINT SEQUENCING

Fertility and Sterility, 2023
Avner Hershlag, Alexandra Peyser, Gheona Altarescu   +2 more
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Transfer of embryos with positive PGT‐M results: Genetic Counselors' perspectives and ethical considerations

Journal of Genetic Counseling
AbstractIncreasing numbers of fertility patients use preimplantation genetic testing for monogenic conditions (PGT‐M) during in vitro fertilization (IVF). While PGT‐M is primarily used to avoid implanting embryos with a monogenic condition, patients can request to transfer an embryo with the monogenic condition (positive embryo transfer), especially in
Silvia Gunderson, Jazmine Gabriel
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IMPACT OF EMBRYO BIOPSY FOR PGT-M TESTING ON PREGNANCY OUTCOMES

Fertility and Sterility, 2023
Evelina Manvelyan, Sunni L. Mumford, Rachel Susan Weinerman   +2 more
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