Results 111 to 120 of about 7,458,423 (270)

Chern-Simons Theory with Sources and Dynamical Quantum Groups I: Canonical Analysis and Algebraic Structures

open access: yes, 2005
We study the quantization of Chern-Simons theory with group $G$ coupled to dynamical sources. We first study the dynamics of Chern-Simons sources in the Hamiltonian framework.
Buffenoir, E., Roche, Ph.
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Context Driven Concept Based Image Retrieval

open access: yesInternational Journal of Information Science and Management, 2012
Several semantic image search schemes have been recently proposed to retrieve images from the web. However, the query context is regularly ignored in these techniques and hence, many of the returned images are not adequately relevant.
H. Vahdatnejad   +3 more
doaj  

Random Walks Estimate Land Value

open access: yes, 2010
Expected urban population doubling calls for a compelling theory of the city. Random walks and diffusions defined on spatial city graphs spot hidden areas of geographical isolation in the urban landscape going downhill.
Blanchard, Ph., Volchenkov, D.
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Biología molecular, una herramienta para la bioprospección del metabolismo secundario de plantas en Colombia Ejemplo práctico en plantas colombianas de interés medicinal

open access: yesRevista Colombiana de Biotecnología, 2004
Los metabolitos secundarios producidos por las plantas están involucrados en una multitud de interacciones ecológicas, entre ellas las interacciones planta-planta, planta-microorganismos, planta-animales y planta-insectos.
Natalia Palacios Rojas   +2 more
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Holistic forecasting for future pandemics: a review of pathogens, models, and data

open access: yesDiscover Public Health
Pandemics challenge the capacity and resilience of healthcare systems around the world. A rapid and effective response to the sudden spread of a pathogen is therefore key to minimising the burden of a disease.
Luis Roger Esquivel Gomez   +9 more
doaj   +1 more source

Home - About - Disclaimer - Privacy