Results 121 to 130 of about 3,645,606 (296)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

QUALITY CONTROL OF pH MEASUREMENTS CONSIDERING ACTIVITY AND CONCENTRATION SCALES: UNCERTAINTY BUDGET OF PRIMARY AND SECONDARY APPARATUSES

, 2006
The concept of pH is very special in the field of physicochemical quantities, because of its widespread use as an important control property and process descriptor and because of the difficulty of defining its theoretical meaning.
P. FISICARO, E. PRENESTI AND S. BERTO, FERRARA, ENZO   +2 more
core  

Context Driven Concept Based Image Retrieval

International Journal of Information Science and Management, 2012
Several semantic image search schemes have been recently proposed to retrieve images from the web. However, the query context is regularly ignored in these techniques and hence, many of the returned images are not adequately relevant.
H. Vahdatnejad, M. A. Nematbakhsh, K. Zamanifar, N. Nematbakhsh   +3 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cordillera Blanca y el Callejón de Huailas (Perú): expedición científica realizada en 1932 por la Sociedad Alpina Alemana y Austríaca, jefe Dr. Ph. Borchers

, 2012
1 Mapa. b/n.- Reducció fotogràfica. - Original: 1:100 000. - Procedència: Fons Reparaz (Mapa 2173).
Borchers, Ph.
core  

pH-Dependent Cellular Internalization of Paramagnetic Nanoparticle

, 2016
A hallmark of the tumor microenvironment in malignant tumor is extracellular acidosis, which can be exploited for targeted delivery of drugs and imaging agents.
Bhuiyan, Mohammed P, James R. Ewing (346426), Branislava Janic (161979), Ewing, James R., Janic, Brana, Janic, Branislava, Ali, Meser M, Mohammed PI. Bhuiyan (2937141), Ewing, James R, Meser M. Ali (162007)   +9 more
core   +1 more source

Biología molecular, una herramienta para la bioprospección del metabolismo secundario de plantas en Colombia Ejemplo práctico en plantas colombianas de interés medicinal

Revista Colombiana de Biotecnología, 2004
Los metabolitos secundarios producidos por las plantas están involucrados en una multitud de interacciones ecológicas, entre ellas las interacciones planta-planta, planta-microorganismos, planta-animales y planta-insectos.
Natalia Palacios Rojas, Daniel Burtin, Mark Leech   +2 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source