Results 101 to 110 of about 4,058,445 (286)

Flexibilisierung der Studienanforderungen in der Lehrerinnen- und Lehrerbildung – Was sagen Studieninteressierte und Studierende?

Beiträge zur Lehrerinnen- und Lehrerbildung
Ausgehend von der Annahme, dass eine höhere Flexibilität bei der Erfüllung der Studienanforderungen zu mehr Attraktivität der Lehrerinnen- und Lehrerbildung und zu besserer Studierbarkeit beitragen kann, werden in diesem Beitrag Äusserungen von ...
Philipp Emanuel Hirsch, Monika Holmeier, Carsten Quesel   +2 more
doaj   +1 more source

PH = PSPACE

IACR Cryptol. ePrint Arch., 2014
The author greatly appreciate suggestions and help of Professor Lew Gordeew and the anonymous reviewers for their comments and ...
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Handlungsrahmen für den Einsatz von Robotern im Mathematikunterricht

Medienimpulse
Im Rahmen des Projekts INTER-DI-KO wurde ein mediendidaktisch fundierter Handlungsrahmen für den Einsatz programmierbarer Roboter im Mathematikunterricht entwickelt und erprobt.
Simon Plangg, Wolf Hilzensauer, Hannah Mayringer, Clarissa Strauß   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Respons Benih Ikan Sidat (Anguilla bicolor bicolor) terhadap Derajat Keasaman (pH)

, 2014
Eels are consumed because it has high content of nutrients, especially vitamin A, EPA and DHA. Demand for eels in the world is very high, therefore the cultivation need to be developed. One of the parameters in eel farming is the pH of the water.
Ritonga, Tamimi Putri TB
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

PH-neutralization.xlsx

, 2018
the neutralization reaction of a strong acid (HNO3, q1), a buffer stream (NaHCO3, q2) and a strong base (NaOH, q3) in the reaction tank. The PH value of the output stream is measurable and determined by the flow rate of inlet (q1~ q3) and outlet (q4). In
Ning Ma (5828084)
core   +1 more source