Results 81 to 90 of about 4,058,445 (286)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Escala de PH

, 2011
Conceitos de PH e misturasSimulador que permite misturar diferentes tipos de substâncias com água para análise do ph.Componente Curricular::Ensino Médio::QuímicaComponente Curricular::Ensino Médio ...
Langdon, Laurie, Adams, Wendy
core   +2 more sources

Fachliches Interesse als Schlüssel zur Studienzufriedenheit: Eine Analyse bei Studierenden der Sonderpädagogik in der Schweiz

Schweizerische Zeitschrift für Bildungswissenschaften
Die Studienzufriedenheit ist ein zentrales subjektives Erfolgsmerkmal im Studium. In einer schweizerischen Ausbildungskohorte (N=646) konnte mittels konfirmatorischer Faktorenanalyse das dreidimensionale Konzept der Studienzufriedenheit erstmals für ...
Sabine Zingg, Sahli Lozano Caroline, Loredana Torchetti   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Life at acidic pH imposes an increased energetic cost for a eukaryotic acidophile

, 2005
Organisms growing in acidic environments, pH <3, would be expected to possess fundamentally different molecular structures and physiological controls in comparison with similar species restricted to neutral pH.
Jung, Sung-Kwon, Zettler, Erik, Messerli, Mark A., Sogin, Mitchell L., Amaral-Zettler, Linda A., Smith, Peter J.S.   +5 more
core   +1 more source

Vrednosti pH mešavina fungicida, insekticida i kompleksnih đubriva, zavisno od kvaliteta vode [PDF]

, 2015
The paper deals with the effect of water quality on the pH value of fungicides, insecticides, mineral fertilizers and their mixtures. The fungicides propineb (Antracol WP-70) and mancozeb (Dithane M-70), insecticides pirimiphos-methyl (Actellic-50) and
Vukovic, Slavica, Klokocar-Smit, Zlata, Indjic, Dusanka, Perovic, Zdravko   +3 more
core  

Caracterización de aleaciones de magnesio mediante microscopía de fuerza atómica con sonda Kelvin de barrido (SKPFM)

Iteckne, 2011
Dos aleaciones de magnesio ZE41 y AZ91D, producidas comercialmente, fueron estudiadas mediante microscopía de fuerza atómica con sonda Kelvin de barrido (SKPFM, siglas en inglés) con el fin de evaluar el papel de sus fases microconstituyentes en ...
Ana Emilse Coy-Echeverría, Fernando Viejo Abrante, Sandra Judith García Vergara, George Thompson, Peter Skeldon, Am Hich   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source