Results 61 to 70 of about 3,645,606 (296)

Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [PDF]

, 2010
Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).
Estime, Nicolas, Biscans, Béatrice, Teychené, Sébastien, Autret, Jean Marie   +3 more
core   +1 more source

Open Access Transformationsvertrag PsyJournals 2022: Hogrefe - IG Hochschulbibliotheken PH (PH-Konsortium)

, 2021
Die IG Hochschulbibliotheken PH und der Hogrefe Verlag überführen hiermit den bestehenden Standort-Lizenzvertrag in einen Transformationsvertrag.
Hogrefe Verlag, PH-Konsortium
core   +1 more source

PENGEMBANGAN SMK MODEL UNTUK MASA DEPAN

Cakrawala Pendidikan: Jurnal Ilmiah Pendidikan, 2013
Abstrak: Praktik penyelenggaraan SMK di Indonesia saat ini menunjukkan kelemahan-kelemahan sebagai berikut: menyelenggarakan fungsi tunggal, yaitu menyiapkan siswa untuk bekerja, untuk menjadi karyawan, dan kurang menyiapkan untuk menjadi wirausahawan ...
Slamet PH PH
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles [PDF]

, 2013
Nanoparticles with pH-sensitive behavior may enhance the success of chemotherapy in many cancers by efficient intracellular drug delivery. Here, we investigated the effect of a bioactive surfactant with pH-sensitive properties on the antitumor activity ...
Vinardell, M. Pilar, Vinardell Martínez-Hidalgo, Ma. Pilar, Mitjans, Montserrat, Mitjans Arnal, Montserrat, Infante, María Rosa, Pérez, Lourdes, Infante Martínez-Pardo, Ma. Rosa, Tavano, Lorena, Nogueira, Daniele R., Nogueira, Daniele Rubert, Pérez Muñoz, Lourdes   +10 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Panorama vom Bodensee : von Lindau bis Rorschach : gezeichnet auf dem Hoyerberg bei Lindau

N. d. Nat. gez. von Ph. Poeppel ; [Jean] Jacottet lith.KreidelithographiePanorama, unten, rechts: "Lindau bei J.
Poeppel, Ph
core   +1 more source

Transformatives Lernen im Hochschulkontext

Zeitschrift für Hochschulentwicklung
Angesichts zunehmender sozialer Ungleichheit sowie der Auswirkungen von Umweltzerstörung und Klimawandel stehen Hochschulen in der Verantwortung, zur Bewältigung dieser Herausforderungen beizutragen.
Ingrid Geier, Robert Hummer, Sandra Milz, Alessandro Barberi   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source