Results 51 to 60 of about 4,223,765 (287)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Panorama vom Bodensee : von Lindau bis Rorschach : gezeichnet auf dem Hoyerberg bei Lindau
N. d. Nat. gez. von Ph. Poeppel ; [Jean] Jacottet lith.KreidelithographiePanorama, unten, rechts: "Lindau bei J.
Poeppel, Ph
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Gender, 2015 Der Beitrag geht der Frage nach, wie im Deutsch- und Mathematikunterricht einer integrativen achten Klasse einer nicht-gymnasialen Schulform Leistung konstruiert und von peerkulturellen, geschlechtsbezogenen Formen überlagert wird.
Tanja Sturm, Monika Wagner-Willi
doaj +1 more source
MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung, 2020 Die Umsetzung des Lehrplans 21, der mit dem Modul «Medien und Informatik» informatische Bildung (IB) in die Schweizer Primarschulen bringen wird, wirft wichtige Fragen auf: Insbesondere fragt sich, wie die Umsetzung gegen die bei vielen ...
Alexander Repenning +2 more
doaj +1 more source
Studies Towards a pH-Sensitive Anticancer Prodrug Model [PDF]
, 2010 Tumour-activated prodrug (TAP) is designed to aim at increasing the prodrug selectivity to kill cancer cells. One strategy to is to design a TAP containing an amine cytotoxin, present as an amide function, which could be released more rapidly in the low ...
Teng, Xiao Shi
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Transformatives Lernen im Hochschulkontext
Zeitschrift für HochschulentwicklungAngesichts zunehmender sozialer Ungleichheit sowie der Auswirkungen von Umweltzerstörung und Klimawandel stehen Hochschulen in der Verantwortung, zur Bewältigung dieser Herausforderungen beizutragen.
Ingrid Geier +3 more
doaj +1 more source