Results 141 to 150 of about 4,058,445 (286)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A Machine Learning Approach That Measures Extracellular pH Within an In Vivo Tumor Model Using acidoCEST MRI. [PDF]

NMR Biomed
Khaled A, Dhakan CB, McCullum LB, de la Cerda J, Schuler FW, Li T, Pagel MD.   +6 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

CASE STUDY: pH MODELING OF A SPREADABLE DAIRY PRODUCT AND SENSORY ANALYSIS

reservedIl presente progetto di tesi è stato proposto dal caseificio Elda s.r.l con l’obiettivo di comprendere l’origine della variabilità del valore di pH del prodotto denominato “latticino spalmabile”.
MARCHI, EMANUELE
core  

pH do solo

, 2008
Through an experience involving a purple cabbage it determines the soil's pH in different samples and observes the acid, basic and neutral pHComponente Curricular::Ensino Fundamental::Séries Finais::Ciências ...
Lima, Marcelo Ricardo de, Yoshioka, Maria Harumi   +1 more
core  

Disentangling Pulmonary Vascular Phenotypes in Group 2 Pulmonary Hypertension Using Bioactive Lipid Profiling. [PDF]

Circ Heart Fail
Garry JD, Brittain EL.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Fatty Acid and Oxylipin Metabolism Differentiate Isolated Postcapillary From Combined Pre- and Postcapillary Pulmonary Hypertension. [PDF]

Circ Heart Fail
Alotaibi M, Tang A, Sun N, Gurholt I, Yuguchi E, Roberts K, Preston I, Warburton R, Yuan JX, Kim NH, Chan SY, Jain M, Cheng S, Hill NS.   +13 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Acidic and alkaline conditions enhance Staphylococcus aureus α-toxin pore formation and cytotoxicity. [PDF]

PLoS Pathog
van der Linden TJ, Chatterjee A, Scheepmaker LM, Chakraborty D, Dutta S, Bardoel BW, Spaan AN.   +6 more
europepmc   +1 more source