Results 51 to 60 of about 6,503 (167)

Controlled Feeding Facilitates the Development of a Robust Production Process for Terpolymeric Polyhydroxyalkanoates

Biotechnology Journal, Volume 21, Issue 6, June 2026.
Graphical Abstract and Lay Summary Cupriavidus necator NCIMB 11599 was cultivated with a fully automated pH–pO2‑dependent feeding strategy that enables controlled levulinic acid delivery and robust production of PHBVV terpolymer. The process was successfully transferred from 7.5 to 42‑L stirred‑tank reactors, maintaining PHA contents of ∼75% CDW and ...
Birk Achenbach, Pravesh Tamang, Steven Leonhardt, Günter E. M. Tovar, Susanne Zibek   +4 more
wiley   +1 more source

In vivo monitoring of PHA granule formation using GFP-labeled PHA synthases

, 2005
For the first time a functional protein was fused to a PHA synthase resulting in PHA granule formation and display of the respective function at the PHA granule surface.
Rehm, BHA, Peters, V, Peters, Verena, Rehm, Bernd H.A.   +3 more
core   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, Volume 15, Issue 19, 22 May 2026.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Exploring Class I polyhydroxyalkanoate synthases with broad substrate specificity for polymerization of structurally diverse monomer units

Frontiers in Bioengineering and Biotechnology, 2023
Polyhydroxyalkanoate (PHA) synthases (PhaCs) are key enzymes in PHA polymerization. PhaCs with broad substrate specificity are attractive for synthesizing structurally diverse PHAs.
Ramamoorthi M Sivashankari, Maierwufu Mierzati, Yuki Miyahara, Shoji Mizuno, Christopher T. Nomura, Seiichi Taguchi, Hideki Abe, Takeharu Tsuge   +7 more
doaj   +1 more source

Nitric Oxide‐Generating Poly (allylamine hydrochloride) Coating on Biomedical Titanium Implant

Advanced Materials Interfaces, Volume 13, Issue 10, 19 May 2026.
We report a metal‐free, nitric oxide (NO)‐generating coating in which poly(allylamine hydrochloride) (PAH) is covalently immobilized onto titanium. The coating catalyzes NO generation from the endogenous S‐nitrosothiol GSNO, retains activity after multiple reuse cycles and pH exposures, and maintains endothelial cell viability while modulating ...
Siti Nur Asyura Adzlan, Kang Lin, Shu Geng, Qingqing Fan, Franco Centurion, Zifei Han, Federico Mazur, Rona Chandrawati   +7 more
wiley   +1 more source

RSM-GA based optimization of bacterial PHA production and in silico modulation of citrate synthase for enhancing PHA production

, 2019
The inexhaustible nature and biodegradability of bioplastics like polyhydroxyalkanoates (PHAs) make them suitable assets to replace synthetic plastics.
El-Enshasy, Hesham A., Shafiul Haque, Vineeta Singh, Bhartendu Nath Mishra, Singh, Vineeta, Apoorva Rao, Hesham A. El-Enshasy, Haque, Shafiul, Rao, Apoorva, Mishra, Bhartendu Nath   +9 more
core   +1 more source

Redefining primary hyperaldosteronism as “The Syndrome of Inappropriate Aldosterone Secretion (SIALDS)”: A common but unrecognized cause of hypertension

The Journal of Clinical Hypertension, 2023
The current screening and diagnostic recommendations for detecting Primary Hyperaldosteronism (PHA) focus on diagnosing the more severe and overt instances of renin‐independent aldosterone production.
Rajat Lamba
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Effect of Phyllanthus amarus Extract on 5-Fluorouracil-Induced Perturbations in Ribonucleotide and Deoxyribonucleotide Pools in HepG2 Cell Line

Molecules, 2016
The aim of this study was to investigate the antitumor activities of Phyllanthus amarus (PHA) and its potential of herb–drug interactions with 5-Fluorouracil (5-FU). Cell viability, ribonucleotides (RNs) and deoxyribonucleotides (dRNs) levels, cell cycle
Jian-Ru Guo, Qian-Qian Chen, Christopher Wai-Kei Lam, Cai-Yun Wang, Feng-Guo Xu, Bu-Ming Liu, Wei Zhang   +6 more
doaj   +1 more source

Technobiological Pathways for High‐CO₂ Capture Using Micro‐/Macroalgae: Genetic Engineering, Process Automation, and Value‐Added Bioproducts

Asia-Pacific Journal of Chemical Engineering, Volume 21, Issue 3, May/June 2026.
ABSTRACT Greenhouse gas (GHG) emissions have emerged as one of the most critical drivers of climate change; this is primarily due to high concentrations and long atmospheric life of carbon dioxide (CO2). For a significant amount of time, various biological processes such as microalgal cultivation, cyanobacterial systems, photosynthetic microorganisms ...
Sadhana Semwal, Harish Chandra Joshi
wiley   +1 more source