Results 11 to 20 of about 531,900 (348)

Phage-Encoded Endolysins [PDF]

Antibiotics, 2021
Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from ...
Fatma Abdelrahman, Maheswaran Easwaran, Oluwasegun I. Daramola, Samar G. Ragab, Stephanie Lynch, Tolulope J Oduselu, F. Khan, A. Ayobami, Fazal Adnan, E. Torrents, S. Sanmukh, Ayman El-Shibiny   +11 more
semanticscholar   +5 more sources

Phage therapy: From biological mechanisms to future directions

Cell, 2023
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago.
S. Strathdee, G. Hatfull, Vivek K. Mutalik, R. Schooley   +3 more
semanticscholar   +1 more source

Isolation and identification of the broad-spectrum high-efficiency phage vB_SalP_LDW16 and its therapeutic application in chickens

BMC Veterinary Research, 2022
Background Salmonella infection in livestock and poultry causes salmonellosis, and is mainly treated using antibiotics. However, the misuse use of antibiotics often triggers the emergence of multi-drug-resistant Salmonella strains.
Shengliang Cao, Wenwen Yang, Xihui Zhu, Cheng Liu, Jianbiao Lu, Zhenshu Si, Lanying Pei, Leilei Zhang, Wensi Hu, Yanlan Li, Zhiwei Wang, Zheyu Pang, Xijuan Xue, Yubao Li   +13 more
doaj   +1 more source

A Roadmap for Genome-Based Phage Taxonomy

Viruses, 2021
Bacteriophage (phage) taxonomy has been in flux since its inception over four decades ago. Genome sequencing has put pressure on the classification system and recent years have seen significant changes to phage taxonomy.
D. Turner, A. Kropinski, Evelien M. Adriaenssens   +2 more
semanticscholar   +1 more source

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

Cell, 2022
Human gut commensals are increasingly suggested to impact non-communicable diseases, such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a daunting unmet challenge.
Sara Federici, S. Kredo-Russo, R. Valdés-Mas, Denise Kviatcovsky, E. Weinstock, Yulia Matiuhin, Yael Silberberg, K. Atarashi, Munehiro Furuichi, A. Oka, Bo Liu, M. Fibelman, I. Weiner, E. Khabra, N. Cullin, Noa Ben-Yishai, D. Inbar, H. Ben-David, J. Nicenboim, Noga Kowalsman, W. Lieb, Edith Kario, T. Cohen, Yael Friedman Geffen, L. Zelcbuch, Ariel Cohen, U. Rappo, I. Gahali-Sass, M. Golembo, V. Lev, Mally Dori-Bachash, H. Shapiro, C. Moresi, Amanda Cuevas-Sierra, Gayatree Mohapatra, Lara Kern, D. Zheng, S. Nobs, Jotham Suez, Noa Stettner, A. Harmelin, N. Zak, S. Puttagunta, M. Bassan, K. Honda, H. Sokol, C. Bang, A. Franke, C. Schramm, N. Maharshak, R. Sartor, R. Sorek, E. Elinav   +52 more
semanticscholar   +1 more source

Immunogenicity of Endolysin PlyC

Antibiotics, 2022
Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms.
Marek Adam Harhala, Katarzyna Gembara, Daniel C. Nelson, Paulina Miernikiewicz, Krystyna Dąbrowska   +4 more
doaj   +1 more source

Considerations for the Use of Phage Therapy in Clinical Practice

Antimicrobial Agents and Chemotherapy, 2022
Increasing antimicrobial resistance and medical device-related infections have led to a renewed interest in phage therapy as an alternative or adjunct to conventional antimicrobials.
G. Suh, T. Lodise, P. Tamma, Jane M. Knisely, J. Alexander, S. Aslam, Karen D. Barton, Erica Bizzell, Katherine M. C. Totten, Joseph Campbell, B. Chan, S. Cunningham, K. Goodman, K. Greenwood-Quaintance, A. Harris, Shayla E Hesse, A. Maresso, V. Nussenblatt, D. Pride, M. Rybak, Zoe M. Sund, D. van Duin, D. Van Tyne, Robin Patel   +23 more
semanticscholar   +1 more source

Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease

Clinical Infectious Diseases, 2022
Background Nontuberculous Mycobacterium infections, particularly Mycobacterium abscessus, are increasingly common among patients with cystic fibrosis and chronic bronchiectatic lung diseases.
R. Dedrick, Bailey E. Smith, Madison Cristinziano, K. Freeman, D. Jacobs-Sera, Y. Belessis, A. Whitney Brown, K. Cohen, R. Davidson, D. van Duin, Andrew B. Gainey, Cristina Berastegui Garcia, C. R. Robert George, G. Haidar, Winnie Ip, J. Iredell, A. Khatami, J. Little, Kirsi Malmivaara, B. McMullan, D. Michalik, A. Moscatelli, J. Nick, M. G. Tupayachi Ortiz, H. Polenakovik, P. Robinson, M. Skurnik, D. Solomon, J. Soothill, H. Spencer, P. Wark, A. Worth, R. Schooley, C. Benson, G. Hatfull   +34 more
semanticscholar   +1 more source

Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice

Nature Biotechnology, 2023
Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic resistance. To develop a phage therapy against a diverse range of clinically relevant Escherichia coli , we screened a library of 162 wild-type (WT) phages ...
Y. E. Gençay, Džiuginta Jasinskytė, Camille Robert, S. Semsey, Virginia Martínez, Anders Ø Petersen, Katja Brunner, Ana de Santiago Torio, Alex Salazar, Iszabela Cristiana Turcu, Melissa Kviesgaard Eriksen, Lev Koval, Adam M. Takos, Ricardo Pascal, T. S. Schou, Lone Bayer, Tina Bryde, Katja Chandelle Johansen, E. G. Bak, F. Smrekar, Timothy B Doyle, M. Satlin, A. Gram, Joana Carvalho, Lene Jessen, Björn Hallström, J. Hink, B. Damholt, Alice Troy, Mette Grove, Jasper Clube, C. Grøndahl, J. Haaber, Eric van der Helm, M. Zdravković, M. Sommer   +35 more
semanticscholar   +1 more source

Phages from Genus Bruynoghevirus and Phage Therapy: Pseudomonas Phage Delta Case [PDF]

Viruses, 2021
The applicability and safety of bacteriophage Delta as a potential anti-Pseudomonas aeruginosa agent belonging to genus Bruynoghevirus (family Podoviridae) was characterised. Phage Delta belongs to the species Pseudomonas virus PaP3, which has been described as a temperate, with cos sites at the end of the genome.
Petar Knezevic, Aleksandra Petrovic Fabijan, Damir Gavric, Jovana Pejic, Zsolt Doffkay, Gábor Rakhely   +5 more
openaire   +4 more sources