Results 41 to 50 of about 359,710 (297)
Microbiology SpectrumRuminococcus gnavus is a prevalent member of human gut microbiota and is associated with inflammatory bowel disease. Phage-based microbiota engineering represents a promising approach for alleviating dysbiosis; however, knowledge regarding R.
Arata Sakiyama +11 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Phage-induced diversification improves host evolvability. [PDF]
, 2013 Bacteriophage (viruses that infect bacteria) are of key importance in ecological processes at scales from biofilms to biogeochemical cycles. Close interaction can lead to antagonistic coevolution of phage and their hosts.
HT Williams (21828014)
core +4 more sources
Emerging Microbes and Infections, 2020 We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp).
Juan Bao +21 more
doaj +1 more source
Isolation and characterisation of Klebsiella phages for phage therapy [PDF]
PHAGE: Therapy, Applications, and Research, 2020 Abstract Klebsiella is a clinically important pathogen causing a variety of antimicrobial resistant infections in both community and nosocomial settings, particularly pneumonia, urinary tract infection and sepsis. Bacteriophage (phage) therapy is being considered as a primary option for the treatment
Eleanor Townsend +12 more
openaire +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Veterinary SciencesDrinking water pipe biofilms, comprising viable microorganisms, microbial residues, and organic/inorganic particulates, pose significant risks to water safety by promoting the proliferation of opportunistic pathogens, pipe corrosion, and degradation of ...
Qinghai Ren +11 more
doaj +1 more source
Phage spanins: diversity, topological dynamics and gene convergence
BMC Bioinformatics, 2018 Background Spanins are phage lysis proteins required to disrupt the outer membrane. Phages employ either two-component spanins or unimolecular spanins in this final step of Gram-negative host lysis.
Rohit Kongari +6 more
doaj +1 more source
Rapid de novo evolution of lysis genes in single-stranded RNA phages
Nature Communications, 2020 Leviviruses are phages with ssRNA genomes that encode a protein (Sgl) that induces host autolysis by interfering with bacterial cell wall synthesis. Identification of sgl genes is complicated by their small size and lack of sequence similarity.
Karthik R. Chamakura +8 more
doaj +1 more source
Case Report: successful use of phage therapy in refractory MRSA chronic rhinosinusitis
International Journal of Infectious Diseases, 2022 We present a case of refractory methicillin-resistant Staphylococcus aureus that was successfully treated with a combination of antibiotics, systemic phage and intranasal phage therapy.
J. Martin Rodriguez +4 more
doaj +1 more source