Results 61 to 70 of about 359,710 (297)
Journal of Genetic Engineering and Biotechnology, 2022 Background Antibiotic-resistant Pseudomonas aeruginosa (P. aeruginosa) is one of the most critical pathogens in wound infections, causing high mortality and morbidity in severe cases.
Nouran Rezk +9 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Nature Communications, 2022 A patient with a multidrug-resistant bacterial infection was successfully treated in 2016 using phage therapy. Here, the authors sequence the genomes of the therapeutic phages and three bacterial strains isolated before and during treatment, and show ...
Mei Liu +14 more
doaj +1 more source
Structural Assembly of Qβ Virion and Its Diverse Forms of Virus-like Particles
Viruses, 2022 The coat proteins (CPs) of single-stranded RNA bacteriophages (ssRNA phages) directly assemble around the genomic RNA (gRNA) to form a near-icosahedral capsid with a single maturation protein (Mat) that binds the gRNA and interacts with the retractile ...
Jeng-Yih Chang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Phage-mediated selection on microbiota of a long-lived host
, 2013 It is increasingly apparent that the dynamic microbial communities of long-lived hosts affect their phenotype, including resistance to disease. The host microbiota will change over time due to immigration of new species, interaction with the host immune ...
Britt Koskella (3290781)
core +4 more sources
Phage-centric ecological interactions in aquatic ecosystems revealed through ultra-deep metagenomics
, 2019 Files containing phage and actinobacterial genomes, associated with the paper "Phage-centric ecological interactions in aquatic ecosystems revealed through ultra-deep metagenomics".Files containing phage and actinobacterial genomes, associated with the ...
Stefan Andrei (684467)
core +1 more source
The effect of ribonuclease on phage-host interaction [PDF]
, 1954 SUMMARY: Pancreatic ribonuclease inhibits the multiplication of a Rhizobium bacteriophage in liquid bacterial cultures by preventing permanent combination between phage and host.
Kleczkowski, A.
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source