Results 51 to 60 of about 327,788 (316)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Biological properties of Vibrio parahaemolyticus lytic phages and transcriptome analysis of their interactions with the host

Aquaculture Reports
Vibrio parahaemolyticus (V. parahaemolyticus) is an opportunistic pathogen primarily affecting aquaculture animals, leading to severe aquatic animal diseases and fatalities.
Duanduan Chen, Zhiwei Wang, Xiangkai Li, Hongchi Du, Kaisheng Zhang, Shengliang Cao, Jianbiao Lu, Shuang Zhao, Hui Wang, Yubao Li   +9 more
doaj   +1 more source

Rapid de novo evolution of lysis genes in single-stranded RNA phages

Nature Communications, 2020
Leviviruses are phages with ssRNA genomes that encode a protein (Sgl) that induces host autolysis by interfering with bacterial cell wall synthesis. Identification of sgl genes is complicated by their small size and lack of sequence similarity.
Karthik R. Chamakura, Jennifer S. Tran, Chandler O’Leary, Hannah G. Lisciandro, Sophia F. Antillon, Kameron D. Garza, Elizabeth Tran, Lorna Min, Ry Young   +8 more
doaj   +1 more source

Exploring phage mechanisms that enhance activity [PDF]

, 2017
In recent years, there has been a renewed interest in using bacteriophages as an alternate agent for the treatment of multi-drug resistant bacteria. One such highly drug-resistant group of bacteria is the Burkholderia cepacia complex (Bcc), which causes ...
Kamal, Fatima
core   +2 more sources

Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis [PDF]

, 2021
Ligand-dependent biosensors are valuable tools for coupling the intracellular concentrations of small molecules to easily detectable readouts such as absorbance, fluorescence, or cell growth.
Ketaki Belsare (11427100), Bryan C. Dickinson (151937), Krysten A. Jones (1616632), Jared C. Lewis (1425370), Harrison M. Snodgrass (7540607)   +4 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Comparative Analysis of Bacterial Diversity and Composition in Oral Fluid from Pigs of Different Ages and Water Pipe Wall Biofilms

Veterinary Sciences
Drinking water pipe biofilms, comprising viable microorganisms, microbial residues, and organic/inorganic particulates, pose significant risks to water safety by promoting the proliferation of opportunistic pathogens, pipe corrosion, and degradation of ...
Qinghai Ren, Wenlong Lu, Tingting Zhang, Shengkai Hao, Jiawen Wang, Xinrui Xu, Fei Wang, Zetong Huang, Xiaojing Lei, Shengliang Cao, Duanduan Chen, Yubao Li   +11 more
doaj   +1 more source

Bacteriophage as a potential therapy to control antibiotic-resistant Pseudomonas aeruginosa infection through topical application onto a full-thickness wound in a rat model

Journal of Genetic Engineering and Biotechnology, 2022
Background Antibiotic-resistant Pseudomonas aeruginosa (P. aeruginosa) is one of the most critical pathogens in wound infections, causing high mortality and morbidity in severe cases.
Nouran Rezk, Abdallah S. Abdelsattar, Doaa Elzoghby, Mona M. Agwa, Mohamed Abdelmoteleb, Rania G. Aly, Mohamed S. Fayez, Kareem Essam, Bishoy M. Zaki, Ayman El-Shibiny   +9 more
doaj   +1 more source

Case Report: successful use of phage therapy in refractory MRSA chronic rhinosinusitis

International Journal of Infectious Diseases, 2022
We present a case of refractory methicillin-resistant Staphylococcus aureus that was successfully treated with a combination of antibiotics, systemic phage and intranasal phage therapy.
J. Martin Rodriguez, Bradford A Woodworth, Bri'Anna Horne, Joseph Fackler, Michael J. Brownstein   +4 more
doaj   +1 more source

Persistence of bacteriophage T4 in a starved Escherichia coli culture: evidence for the presence of phage subpopulations. [PDF]

, 2011
Bacteriophage T4 is able to adjust its development to the growth parameters of the host cell. Here, we present evidence for the production of two different subpopulations of phage particles, which differ in their ability to infect starved Escherichia ...
Wiczk, Aleksandra, Łoś, Marcin, Konopa, Grażyna, Węgrzyn, Grzegorz, Golec, Piotr, Łoś, Joanna M   +5 more
core