Results 81 to 90 of about 327,788 (316)

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Large-genome phage vB_Eco_ZCEC15 targets gastrointestinal MDR E. coli: evidence from in vitro and Caco-2 cell models

BMC Microbiology
Background Bacterial resistance to traditional antibiotics is spreading at an alarming rate, threatening public health and various industrial applications.
Kareem Essam, Amira A. Mohamed, Salsabil Makky, Azza G. Kamel, Ayman El-Shibiny   +4 more
doaj   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Comprehensive epidemiological profiling of poultry-derived Salmonella spp. in Shandong, China, 2019–2022: a longitudinal study of prevalence, antibiotic resistances, virulence factors and molecular characteristics

Frontiers in Microbiology
Salmonella spp., as a major foodborne pathogen, pose significant threats to public health globally and has been an important zoonotic contamination for poultry industry that should receive increasing attentions.
Lele Chen, Lele Chen, Yuxia Shi, Yuxia Shi, Minge Wang, Minge Wang, Yubao Li, Zhenshu Si, Zhenshu Si   +8 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

The promise of phages

Nature Biotechnology, 2023
Phage therapy is an exciting alternative to antibiotics. Why now?
openaire   +2 more sources

Addressing the research and development gaps in modern phage therapy [PDF]

Antimicrobial resistance is on the rise globally, prompting increased research and development (R&D) of phage therapy as a strategy to address difficult-to-treat bacterial infections. We review the current state of phage therapy research, including major
Turner, Paul, Moreno, Mercedes Gonzalez, Azeredo, Joana, Haaber, Jakob Krause, Portillo, Mirza Alas, Green, Sabrina, Kameda de Figueiredo Carvalho, Koichi, Haggstrom, Douglas, Kirchhelle, Claas, Carvalho, Koichi Kameda de Figueiredo, Pirnay, Jean-Paul, Gonzalez Moreno, Mercedes, Buurman, Ed. T., Buurman, Ed, Turner, Paul E.   +14 more
core   +1 more source

Construction of Synthetic Antibody Phage-Display Libraries [PDF]

, 2017
Synthetic antibody libraries provide a vast resource of renewable antibody reagents that can rival or exceed those of natural antibodies and can be rapidly isolated through controlled in vitro selections.
Nilvebrant, Johan,, Sidhu, S. S., Sachdev S. Sidhu, Johan Nilvebrant   +3 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Structural basis of Acinetobacter type IV pili targeting by an RNA virus

Nature Communications
Acinetobacters pose a significant threat to human health, especially those with weakened immune systems. Type IV pili of acinetobacters play crucial roles in virulence and antibiotic resistance.
Ran Meng, Zhongliang Xing, Jeng-Yih Chang, Zihao Yu, Jirapat Thongchol, Wen Xiao, Yuhang Wang, Karthik Chamakura, Zhiqi Zeng, Fengbin Wang, Ry Young, Lanying Zeng, Junjie Zhang   +12 more
doaj   +1 more source