Results 221 to 230 of about 327,788 (316)
The uncharacterized <i>E. coli</i> gene <i>ybjD</i> encodes a novel Class 1 OLD protein. [PDF]
MicroPubl BiolAtahualpa LT +3 more
europepmc +1 more source
Microbiome–Driven Carcinogenesis and Circulating Microbial Signals in Genitourinary Cancers
Cancer Science, EarlyView.Experimental BBN models link gut microbial metabolism and diet‐microbiome interactions to urothelial carcinogenesis, while circulating extracellular vesicle‐associated bacterial DNA signals may reflect tumor immune contexture and immune checkpoint inhibitor outcomes in urothelial and renal cell carcinoma.
Atsunari Kawashima +12 more
wiley +1 more source
Cell Proliferation, EarlyView.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
Morphological and complete genome analysis of a novel <i>Clostridium perfringens</i> phage CpP_VarHS, isolated from wastewater. [PDF]
Front PharmacolSaghrouchni H +3 more
europepmc +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, EarlyView.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources
The FEBS Journal, EarlyView.This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani +8 more
wiley +1 more source
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
Extracellular activity of a bacterial protease associated with reduced phage infectivity. [PDF]
PLoS OneHerbst E +5 more
europepmc +1 more source