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A phage cocktail for drug-resistant mycobacteria [PDF]
Nature Reviews Microbiology, 2019 This study reports the use of a three-phage cocktail in the treatment of disseminated drug-resistant Mycobacterium abscessus.
York Ashley
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Shopping for phages? Unpacking design rules for therapeutic phage cocktails
Current Opinion in Virology, 2022In bacteriophage therapy, the combination of different phages into a single cocktail is of critical importance to overcome the narrow host range of single phage isolates. Today, the design of therapeutic cocktails is often akin to a black box and relies largely on intuition and (pre-)availability of isolates in local collections.
Cédric Lood +3 more
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Computational design of phage cocktails based on phage-bacteria infection networks
Computers in Biology and Medicine, 2022The misuse and overuse of antibiotics have boosted the proliferation of multidrug-resistant (MDR) bacteria, which are considered a major public health issue in the twenty-first century. Phage therapy may be a promising way in the treatment of infections caused by MDR pathogens, without the side effects of the current available antimicrobials.
Manuel Menor-Flores +2 more
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Phage and phage cocktails formulations
2023Antibiotic-resistant bacterial infection is a major global problem and can be life-threatening. Bacteriophages or phages can be substituted choice over traditional antibiotics treatments. Phages are natural obligate parasites viruses of bacteria, and they can infect and kill antibiotic-sensitive and -resistant bacteria.
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Phage Cocktail Therapy: Multiple Ways to Suppress Pathogenicity
Trends in Plant Science, 2020Phage cocktails have emerged as precision tools for controlling plant bacterial diseases. Wang et al. now report that phage cocktails decreased the occurrence of tomato bacterial wilt disease efficiently by infecting and destroying bacterial pathogens, selecting phage-resistant but slow-growing pathogen strains, and fostering bacterial species that are
Na, Liu +3 more
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In Vitro Evaluation of a Phage Cocktail Controlling Infections with Escherichia coli [PDF]
Viruses, 2020 Worldwide, poultry industry suffers from infections caused by avian pathogenic Escherichia coli. Therapeutic failure due to resistant bacteria is of increasing concern and poses a threat to human and animal health. This causes a high demand to find alternatives to fight bacterial infections in animal farming.
Imke H E Korf +2 more
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New Phage cocktail against infantile Sepsis bacteria
Microbial Pathogenesis, 2020A total of 54 positive blood aerobic cultures of suspected blood sepsis in neonates were purified, diagnosed and tested for antibiotic susceptibility. Six bacterial pathogens of Escherichia coli (10 isolates), Klebsiella pneumoniae (10 isolates), Haemophilus influenzae (4 isolates), Pseudomonas aeruginosa (3 isolates), Citrobacter fruendii (1 isolate ...
Sadeq Abdulridha, Gatea Kaabi +1 more
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A Novel Method to Create Efficient Phage Cocktails via Use of Phage-Resistant Bacteria
Applied and Environmental Microbiology, 2022The rapid antiphage mutation of pathogens is a big challenge often encountered in phage therapy. Using a cocktail composed of phages with different infection strategies can better overcome this problem.
Chengcheng Li +3 more
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