Results 141 to 150 of about 171,183 (250)

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang, Xinxin Liu, Gido Gravesteijn, Alessia Atella, Jin Liu, Julie W. Rutten, Peter ten Dijke, Manuel A. F. V. Gonçalves, Saskia A. J. Lesnik Oberstein, David A. Baker   +9 more
wiley   +1 more source

Bacteriophages with potential to inactivate Salmonella Typhimurium: Use of single phage suspensions and phage cocktails

Virus Research, 2016
The aim of this study was to compare the dynamics of three previously isolated bacteriophages (or phages) individually (phSE-1, phSE-2 and phSE-5) or combined in cocktails of two or three phages (phSE-1/phSE-2, phSE-1/phSE-5, phSE-2/phSE-5 and phSE-1/phSE-2/phSE-5) to control Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) in order to ...
Carla, Pereira, Catarina, Moreirinha, Magdalena, Lewicka, Paulo, Almeida, Carla, Clemente, Ângela, Cunha, Ivonne, Delgadillo, Jésus L, Romalde, Maria L, Nunes, Adelaide, Almeida   +9 more
openaire   +2 more sources

Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
An AlphaFold 2 model of a peptide derived from zinc finger translocation associated (ZFTA) protein in complex with the Kelch domain of KLHL20 (KLHL20Kelch). Sensorgrams from surface plasmon resonance biosensor experiments of the interaction between a ZFTA‐derived peptide with immobilised KLHL20Kelch shows that the interaction is complex and has a ...
Nadine E. M. Myers, Joanna Whittaker, Marie Elodie Hélène Cadot, Julia K. Varga, Marcel Diallo, Jakob Nilsson, Anders Bach, Anja Sandström, Ora Schueler‐Furman, U. Helena Danielson   +9 more
wiley   +1 more source

Development of a Bacteriophage Cocktail to Evaluate In Vitro and In Vivo Therapeutic Efficacy Against ESBL Producing Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance
INTRODUCTION: Klebsiella pneumoniae as commensal Gram-negative bacilli and a member of ESKAPE pathogens is common cause of bacteremia, endocarditis, wound, respiratory and urinary tract infections.
Sidrah Asghar, Ayaz Ahmed
doaj   +1 more source

Determinants of Phage Host Range in Staphylococcus Species. [PDF]

, 2019
Bacteria in the genus Staphylococcus are important targets for phage therapy due to their prevalence as pathogens and increasing antibiotic resistance.
Lindsay, JA, Moller, AG, Read, TD
core   +1 more source

Efficacy of a phage cocktail in controlling phage resistance development in multidrug resistant Acinetobacter baumannii

Virus Research, 2019
The control and treatment of multidrug resistant pathogens infections has become a grand challenge for clinicians worldwide. Virulent phage has long been considered as an effective bactericidal agent, which may be a potentially alternative to antibiotics.
Yuyu, Yuan, Lili, Wang, Xiaoyu, Li, Demeng, Tan, Cong, Cong, Yongping, Xu   +5 more
openaire   +2 more sources

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants [PDF]

, 2017
RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic processes and have been implicated in numerous diseases, but targeting these enzymes remains a major challenge.
Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads, Huang, Danny T., Nakasone, Mark A., Sibbet, Gary J., Sidhu, Sachdev S., Smith, Brian O., Zhang, Wei   +8 more
core   +3 more sources

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Synergistic Interaction Between Phage Therapy and Antibiotics Clears Pseudomonas Aeruginosa Infection in Endocarditis and Reduces Virulence. [PDF]

, 2017
Increasing antibiotic resistance warrants therapeutic alternatives. Here we investigated the efficacy of bacteriophage-therapy (phage) alone or combined with antibiotics against experimental endocarditis (EE) due to Pseudomonas aeruginosa, an archetype ...
Entenza, J.M., Gabard, J., Mancini, S., Moreillon, P., Oechslin, F., Piccardi, P., Que, Y.A., Resch, G.   +7 more
core   +1 more source