Results 151 to 160 of about 171,183 (250)

Antimicrobial Resistance in Cancer Care: Challenge and Path Forward

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Introduction Antimicrobial resistance (AMR) is a global health crisis that poses a devastating and specific threat to immunocompromised cancer patients, who are heavily reliant on antibiotics to navigate high‐risk treatments. The rapid emergence of multidrug‐resistant (MDR) pathogens compromises the efficacy of prophylaxis and empirical ...
Majani Edward, Ameh Wisdom Owoicho
wiley   +1 more source

Rapid resistance evolution against phage cocktails

When bacteria are treated with multiple antibiotics simultaneously, resistance is exceedingly unlikely to evolve. In stark contrast, resistance against multiple phages frequently arises during therapy. Why does resistance against multi-phage cocktails evolve so easily?
Baltus A van der Steen, Matti Gralka, Yuval Mulla   +2 more
openaire   +1 more source

Akkermansia muciniphila enhances chicken resistance to infectious bronchitis virus by boosting GABA synthesis and suppressing the NF‐κB inflammatory pathway

iMetaOmics, Volume 3, Issue 1, March 2026.
Infectious bronchitis virus (IBV) represents a major threat to poultry production, with current control strategies offering limited protection. In this study, we demonstrate gut microbiome is a critical determinant of IBV resistance using fecal microbiota transplantation.
Ouyang Peng, Yufang Liu, Xuanci Wang, Yihui Huang, Yiqin Yang, Qixiang Kang, Rui Geng, Guangli Hu, Aiping Lv, Fangyu Hu, Yongbo Xia, Xin Luo, Jiamin Liao, Yihong He, Zhanpeng Kuang, Yunping Du, Yun Zhang, Chunyi Xue, Zongxi Han, Wen‐Jun Li, Lei Dong, Hao Zhang, Yongchang Cao   +22 more
wiley   +1 more source

Mining for viral fragments in methylation enriched sequencing data [PDF]

, 2015
Most next generation sequencing experiments generate more data than is required for the experimental set up. For example, methyl-CpG binding domain (MBD) affinity purification based sequencing is often used for DNA-methylation profiling, but up to 30% of
Ed eSchuuring, G. Bea A. Wisman, Klaas eMensaert, Olivier eThas, Renske D. M. Steenbergen, Tim eDe Meyer, Wim eVan Criekinge, Wim eVan Criekinge   +7 more
core   +4 more sources

Bacteriophage Therapy: Current Strategies and Future Perspectives

MedComm, Volume 7, Issue 3, March 2026.
This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou, Hanyu Fu, Mengzhe Li, Zhongyu Han, Zhenchao Wu, Huahao Fan, Ning Shen, Jiajia Zheng   +7 more
wiley   +1 more source

Precision Microbial Therapeutics for Infertility: Next‐Generation Probiotics, Engineered Biologics and Translational Pathways

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
Major reproductive‐tract microbiome endotypes and their clinical associations. L. crispatus dominance supports acidification and immune tolerance conducive to implantation. L. iners dominance represents an unstable state linked to bacterial vaginosis and reduced implantation.
Limiao Li, Lin Feng, Qiang Li, Yue Zhou, Sifan Liu, Huimin Song, Shengnan Kang, Huike Chen, Huifang Cong, Shumin Liu   +9 more
wiley   +1 more source

Modeling the architecture of depolymerase-containing receptor binding proteins in Klebsiella phages [PDF]

, 2019
Klebsiella pneumoniae carries a thick polysaccharide capsule. This highly variable chemical structure plays an important role in its virulence. Many Klebsiella bacteriophages recognize this capsule with a receptor binding protein (RBP) that contains a ...
Briers, Yves, Drulis-Kawa, Zuzanna, Leiman, Petr G, Łątka, Agnieszka   +3 more
core   +2 more sources

A Review of Phage Therapy for Aquaculture Applications: Efficacy, Health Ramifications and Research Challenges

Fish and Fisheries, Volume 27, Issue 2, Page 300-312, March 2026.
Bacteriophage therapy is characterised by numerous advantages, facilitating its diverse aquaculture application and efficacy as an antibiotic alternative mitigating the spread of antimicrobial‐resistant pathogens. Contributing to the modern reappraisal of the aquaculture application of bacteriophage therapy, challenges impeding its widespread ...
Louise James, Tamsyn M. Uren Webster, Gethin Thomas, Mathias Middelboe, Sofia Consuegra   +4 more
wiley   +1 more source

Development of an Acid-Protective Polymer Encapsulation Formulation for Oral Delivery of Salmonella Phages

Viruses
Bacteriophage therapy can successfully provide additional treatment to control Salmonella infection, but low gastric pH limits its oral application. The present study aimed to develop an improved encapsulation formulation with enhanced acid protection ...
Manju Bernela, Nitin Virmani, Bidhan Chand Bera, Rajesh Kumar Vaid, Medhavi Vashisth, Taruna Anand   +5 more
doaj   +1 more source

Structural investigation of human U6 snRNA recognition by spliceosomal recycling factor SART3 RNA recognition motifs

The FEBS Journal, Volume 293, Issue 5, Page 1323-1340, March 2026.
Human SART3 has two RRM domains to engage with U6 snRNA for spliceosome recycling. This study reports solution structures of SART3 RRM domains and investigates the interaction between RRM and U6 snRNA. SART3 binds to the asymmetric bulge of U6 snRNA as a dimer via conserved positively charged surfaces.
Iktae Kim, Kyeong‐Mi Bang, So Young An, Changkon Park, Ji‐Yeon Shin, Youngim Kim, Hyun Kyu Song, Jeong‐Yong Suh, Nak‐Kyoon Kim   +8 more
wiley   +1 more source