Results 201 to 210 of about 165,430 (355)

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Genome Sequence of Mycobacterium Phage Guppsters.

microPublication biology
Mycobacterium Phage Guppsters was isolated on Mycobacterium smegmatis mc 2 155, displays a siphovirus morphology, and possesses a 54,835 base pair genome. Based on gene content similarity, Guppsters is assigned to cluster F1. Unlike a majority of F1 phages, Guppsters does not encode mycobacteriophage mobile elements.
Alley, Emma K, Hill, Lexi C, Houglum, Mya E, Lamppa, Maggie R, Pack, Khailee K, Pageau, Hailey D, Prosen, Cale J, Richards, Kylie R, Royer, Kendra S, Slettedahl, Emily A, Strusz, Ian L, Wiita, Lydia A, Zeidler, Jillian C, Westholm, Daniel E   +13 more
openaire   +2 more sources

Isolation and characterization of new lytic bacteriophage PSA-KC1 against Pseudomonas aeruginosa isolates from cystic fibrosis patients

Scientific Reports
A novel lytic bacteriophage, PSA-KC1, was isolated from wastewater. In this study, the whole genome of the bacteriophage PSA-KC1 was analyzed, and its lytic properties were assessed.
Kübra Can Kurt, Halil Kurt, Edip Tokuç, Doğukan Özbey, Duygu Nur Arabacı, Sevcan Aydın, Nevriye Gönüllü, Mikael Skurnik, Hrisi Bahar Tokman   +8 more
doaj   +1 more source

Genome Sequence of Arthrobacter Phage Sourignavong.

microPublication biology
We report the genome sequence of phage Sourignavong isolated from soil in Oklahoma City, Oklahoma using Arthrobacter sp. ATCC 21022. The 15,625 bp genome contains 27 predicted protein coding genes, including two predicted endolysin enzyme genes. Sourignavong is assigned to actinobacteriophage cluster AN.
Rife, Ian T., Sannomiya, Nana, Thai, Katie N., Williams, Cori B., Amasol-Tanoura, Raelynn A., Arca, Jennifer H., Bradley, Gillian A., Catlin, Avery C., Edwards, Saige A., Faria, Sophia F., Fuentes-Ayala, Maximilliano, Gantenbein, Lola M., Haiges, Alexis M., Hart, Hailey E., Herrera, Ayden K., Karlin, Paisley J., Schumaker, Landon H., Velasquez, Emily J., Moon, Hannah E., Porter, Megan L.   +19 more
openaire   +2 more sources

FhuA-mediated phage genome transfer into liposomes

, 2001
Jochen Böhm, Olivier Lambert, Achilleas S. Frangakis, Lucienne Letellìer, Wolfgang Baumeister, Jean Louis Rigaud   +5 more
openalex   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, EarlyView.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

The Temperate Marine Phage ΦHAP-1 of Halomonas aquamarina Possesses a Linear Plasmid-Like Prophage Genome [PDF]

, 2008
Jennifer M. Mobberley, R. Nathan Authement, Anca M. Segall, John H. Paul   +3 more
openalex   +1 more source

Ancient, recurrent phage attacks and recombination shaped dynamic sequence-variable mosaics at the root of phytoplasma genome evolution [PDF]

, 2008
Wei Wei, Robert E. Davis, R. Jomantienė, Yan Zhao   +3 more
openalex   +1 more source

Making Molecular Diagnostics Faster

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Over the past 40 years, molecular diagnostic methods have evolved from multi‐step, time‐consuming protocols towards either rapid targeted tests or expansive, massively parallel testing. Aims Here we consider the speed limits of targeted molecular diagnostics, considering the three sequential required steps: nucleic acid preparation,
Carl T. Wittwer, Luming Zhou, Felix Ye, Adam Millington, Adrian de Cola, Noriko Kusukawa   +5 more
wiley   +1 more source