Results 191 to 200 of about 126,149 (256)

Mechanisms of Resistance, Insights From Case Reports, and Future Prospects in Mycobacteriophage Therapy

open access: yesJournal of the Royal Society of New Zealand, Volume 56, Issue 4, August 2026.
Evolution of drug‐resistant mycobacterial infections warrants renewed efforts in identifying more efficient preventive and control strategies as well as alternative treatment options. Interest in phage therapy is regaining significant traction, especially in cases of failed conventional therapy.
Buhari Yusuf   +10 more
wiley   +1 more source

Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems

open access: yesMicrobial Biotechnology, Volume 19, Issue 8, August 2026.
Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Fungicide Drives De Novo Evolution of Multidrug Resistance in the Plant Growth Promoting Rhizobacterium, Pseudomonas fluorescens

open access: yesEvolutionary Applications, Volume 19, Issue 8, August 2026.
ABSTRACT Soil microbial communities underpin key ecosystem processes, including plant health, nutrient cycling and primary productivity. In agricultural soils, beneficial soil bacteria are often exposed to multiple stressors simultaneously, including fungicides, antibiotics, and warming temperatures. Despite their ecological importance, little is known
Matthew Kelbrick   +2 more
wiley   +1 more source

The TG2/LRP1 Pathway for T Cell Activation by Post‐Translationally Modified Antigens

open access: yesImmunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Post‐translational modifications (PTMs) can generate neo‐epitopes, modified peptides that evade immune tolerance and trigger immune responses. This review focuses on the TG2/LRP1 pathway as a new paradigm for coupling the formation of post‐translationally modified peptides with their effective presentation as T‐cell antigens by dendritic cells.
Agnele Sylvia Sewa   +2 more
wiley   +1 more source

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