Results 191 to 200 of about 1,053,752 (301)

Phage Therapy and Phage Engineering technologies for tackling Antibiotic-Resistance in Bacterial Infections

openIn recent years, the escalating crisis of antibiotic resistance has spurred the search for alternative antimicrobial strategies, with bacteriophage therapy emerging as a promising candidate.
ORLANDI, SIMONE
core  

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Cancer Science, EarlyView.
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng   +11 more
wiley   +1 more source

Genome Sequence of Arthrobacter Phage StuartMinion.

microPublication biology
Bacteriophage StuartMinion, isolated from an environmental sample collected in Kunia, Hawai'i, has a siphovirus morphology and is capable of infecting Arthrobacter globiformis B-2979. The genome is 35,207 bps, with 61 predicted genes and a GC content of 66.40%.
Adamson, Moriah A., Matsueda, Hailey M., Shepp, Ava S.G., Nguyen Tran, Duy Linh, Aperocho, Noellani Shantel C., Baek-Kim, Trinity S., Dizon, Ashley S., Gibson, Makala A., Hendrickson, Kalia M., Lu, Yen Nhu K., Mcnulty, Keira, Molina, Mia S., Neighbarger, Elijah K., Redwine, Amber, Takenaka, Denise K., Taketa, Kyli N., Walker, Taylor A., Spotkaeff, Cherise, Wallace, Rin, Donachie, Stuart, Culley, Alexander, Porter, Megan L.   +21 more
openaire   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Modulation of sebocyte function in acne: A pathway‐inclusive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis, Apostolos Pappas, Katja Martin, Mauro Picardo   +3 more
wiley   +1 more source

Development of a Multiplex Polymerase Chain Reaction Assay for Differentiating Three Lactococcus Species Associated With Piscine Lactococcosis

Journal of Fish Diseases, EarlyView.
ABSTRACT Piscine lactococcosis is an important bacterial disease of farmed fish. The causative agents, Lactococcus garvieae, Lactococcus petauri and Lactococcus formosensis, are closely related, which complicates species‐level identification. We developed a conventional multiplex PCR assay targeting species‐specific genes identified by comparative ...
Tomoaki Yoshino, Tomokazu Takano, Hiroki Tanno, Yukihiro Nakagawa, Yuta Matsuura, Shogo Harakawa, Hidehiro Kondo, Ikuo Hirono, Keiichiro Koiwai, Tomomasa Matsuyama   +9 more
wiley   +1 more source

Structure‐Based Annotation by AlphaFold3 Predictions of the Francisella halioticida T6SS Encoded in the Francisella Pathogenicity Island

Journal of Fish Diseases, EarlyView.
ABSTRACT Francisella halioticida has emerged as a significant pathogen of cultured molluscs, causing substantial economic losses due to mass mortalities. The Francisella Pathogenicity Island encodes a Type VI secretion system essential for virulence and intracellular persistence. However, the F.
Hélène Bouras, Céline Zatylny‐Gaudin, Eric Duchaud   +2 more
wiley   +1 more source

Decoding and reengineering the promoter specificity of T7-like RNA polymerases based on phage genome sequences. [PDF]

Nucleic Acids Res
Zhu J, Liu Z, Lou C, Chen Q, Liu H.
europepmc   +1 more source

Development and Application of a Novel qPCR Assay for Quantifying Flavophage FpV‐4 Against Flavobacterium psychrophilum

Journal of Fish Diseases, EarlyView.
ABSTRACT Bacteriophage (phage) therapy is increasingly being used to control Flavobacterium psychrophilum impacts upon the health and production of salmonid aquaculture worldwide, and FpV‐4 is a phage commonly utilised for the mitigation of F. psychrophilum outbreaks. While quantitative PCR (qPCR) methods are often used for quantifying F. psychrophilum,
Louise James, Tamsyn M. Uren Webster, Benjamin Overland, Arun M Shankregowda, Gethin Thomas, Mathias Middelboe, Valeria Ruffo, Sofia Consuegra   +7 more
wiley   +1 more source