Results 171 to 180 of about 125,595 (262)

Rates of Mutation and Recombination in Siphoviridae Phage Genome Evolution over Three Decades. [PDF]

Mol Biol Evol, 2018
Kupczok A, Neve H, Huang KD, Hoeppner MP, Heller KJ, Franz CMAP, Dagan T.   +6 more
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Schematic illustration on a therapeutic strategy wherein engineered extracellular vesicles (EVs) are delivered intranasally and specifically target pericytes. In a model of chronic cerebral hypoperfusion (BCAS), this targeted approach preserves cerebral blood flow, reinforces blood‐brain barrier (BBB) integrity, stabilizes the neurovascular unit (NVU),
Weiwei Shen, Weishi Liu, Min Guo, Tongyao You, Yingzhe Wang, Tiansiyu Wen, Suzhen Liang, Xiaodi Xie, Yanfeng Jiang, Qiang Dong, Jin‐Tai Yu, Mei Cui   +11 more
wiley   +1 more source

Reverse Genetics of Orthoflaviviruses: Strategies for Constructing Functional or Infectious cDNA

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Reverse genetics (RG) systems have transformed RNA virus research by enabling the recovery of recombinant viruses entirely from cloned cDNA. These platforms allow precise, hypothesis‐driven manipulation of viral genomes and support systematic phenotypic analyses in vitro and in vivo.
Young‐Min Lee
wiley   +1 more source

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha, Raine Piva Amaral, Ana Luisa Cauvila dos Santos, Bárbara Rafaela Ferreira Aio, Maria Fernanda Romboli Durante, Luiz Cosme Cotta Malaquias, Gabriel Magno de Freitas Almeida, Luiz Felipe Leomil Coelho   +7 more
wiley   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

Unveiling Marine Vesicle Uptake in Vibrio spp: Taxonomic and Environmental Insights

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Extracellular vesicles are involved in diverse functions in nature from microbial interactions to pathogenesis. Here, we investigate whether taxonomy represents a boundary that constrains the uptake of vesicles between different marine bacteria including ubiquitous Vibrio spp. involved in marine organism diseases, such as corals.
Nadefa Adda Nekrouf, Lucia Maestre‐Carballa, Monica Lluesma‐Gomez, Esther Rubio‐Portillo, Manuel Martinez‐Garcia   +4 more
wiley   +1 more source

Integrative Modular, Network‐Based, and Machine Learning Framework for Predicting Accessory Genome Functions and Virulence in Escherichia coli O157:H7

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
An analysis of the accessory genomes from 77 Escherichia coli O157:H7 strains using network and machine learning techniques uncovers modular communities of plasmid‐related virulence associated with IncF replicons. Accessory markers that are not directly linked to toxin genes can effectively predict the virulence status with an AUC of 0.85, facilitating
Sydney Menzeko Gambushe, Oliver Tendayi Zishiri   +1 more
wiley   +1 more source

Complete genome sequence of <i>Cronobacter muytjensii</i> bacteriophage vB_Cmu_VP5. [PDF]

Microbiol Resour Announc
Durovka P, Minich A, Sedlackova T, Kajsik M.   +3 more
europepmc   +1 more source

The Landscape of Salmonella enterica Serovar Gallinarum–Pullorum Antimicrobial Resistance in Bangladesh's Poultry Industry: A Combined Phenotypic and Molecular Study

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Salmonella enterica serovar Gallinarum–Pullorum isolated from chickens reveals a critical 89.13% prevalence of multidrug resistance. High phenotypic resistance to amoxicillin and tetracycline is genetically underpinned by a robust presence of resistance‐conferring genes (notably tetA, sul1, and blaCMY), highlighting a significant zoonotic threat to ...
Md. Masuk Rahman Kingshuk, Shanzida Binte Alam, Md. Shajedur Rahman, Md. Nurnoby Islam   +3 more
wiley   +1 more source