Results 221 to 230 of about 190,753 (310)

“More” Artificial mRNAs: Beyond the Art of Nature

open access: yesAdvanced Science, Volume 13, Issue 20, 9 April 2026.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui   +3 more
wiley   +1 more source

CircRSU1 Activates the hnRNPA1/HIF‐1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma

open access: yesAdvanced Science, Volume 13, Issue 22, 17 April 2026.
This study reveals circRSU1 with important oncogenic roles in hepatocellular carcinoma (HCC). CircRSU1, highly abundant in HCC, interacts with and stabilizes hnRNPA1 from ubiquitination and degradation. This stabilization facilitates hnRNPA1 binding to the internal ribosome entry site of HIF1A to increase HIF‐1α protein translation.
Shuting Xue   +14 more
wiley   +1 more source

FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization

open access: yesAdvanced Science, Volume 13, Issue 23, 23 April 2026.
Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan   +17 more
wiley   +1 more source

Ultrasound‐Responsive Engineered Bacteria for Targeted Cancer Therapy: Strategies, Mechanisms, and Applications

open access: yesAdvanced Science, Volume 13, Issue 20, 9 April 2026.
This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang   +5 more
wiley   +1 more source

Dietary Probiotics Improve Growth, Immunity and Disease Resistance in Fish Against Aeromonas hydrophila Infection

open access: yesAquaculture, Fish and Fisheries, Volume 6, Issue 2, April 2026.
Probiotics offer a promising alternative to antibiotics for managing Aeromonas hydrophila infections in aquaculture. Dietary supplementation of probiotics increases fish health, growth performance, and immune responses, while reducing antibiotic reliance in fish farming.
Md. Ridwanul Islam   +3 more
wiley   +1 more source

Influence of Gut Microbiota on Response to Immune Check Point Inhibitors in MASLD Patients With HCC: Unraveling the Connection

open access: yesCancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Immune checkpoint inhibitors (ICIs) have emerged as a promising treatment for various cancers, including advanced hepatocellular carcinoma (HCC). However, a significant proportion of patients with HCC, particularly those with metabolic dysfunction‐associated liver disease (MASLD), exhibit resistance to ICI therapy.
Mazen Elsheikh   +9 more
wiley   +1 more source

Solar‐Driven In Situ Hydrogen Peroxide Production Over Metal‐Free Carbon Nitrides for Environmental Remediation

open access: yesChemPhotoChem, Volume 10, Issue 4, April 2026.
This minireview discusses solar‐driven in situ H2O2 production using metal‐free g‐C3N4 photocatalysts for environmental remediation. It highlights reaction mechanisms, synthesis, and material engineering approaches that enhance light absorption, charge separation, and selectivity, enabling efficient pollutant degradation, biomass oxidation, and ...
Zunaira Muhammad   +3 more
wiley   +1 more source

Impact of OMICS Technologies in Our Understanding of the Pathogenesis of Peri‐Implantitis

open access: yesClinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objectives To evaluate the contribution of OMICS technologies to the understanding of peri‐implantitis pathogenesis from a host immune perspective. Materials and Methods A narrative review was conducted based on electronic searches of PubMed, MEDLINE, and Google Scholar up to October 2025, complemented by manual screening of reference lists ...
Farah Asa'ad   +6 more
wiley   +1 more source

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