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Phage Vaccines and Phage Therapy
2011The application of combinatorial approaches in conjunction with phage display techniques might be critical for development of vaccines against various infective and cancer diseases. Phage technique allows the generation of novel immunogens representing structural/molecular mimics of pathogen-derived immunodominant epitopes, or protein domains displayed
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2005
Abstract The ability of bacteriophage (phage) to replicate exponentially and lyse pathogenic strains of bacteria suggests that they should play a vital role in our armamentarium for the treatment of infectious diseases. However, in spite of an initial enthusiasm, early clinical applications resulted in a negative shift of opinion ...
Carl R Merril, Dean Scholl, Sankar Adhya
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Abstract The ability of bacteriophage (phage) to replicate exponentially and lyse pathogenic strains of bacteria suggests that they should play a vital role in our armamentarium for the treatment of infectious diseases. However, in spite of an initial enthusiasm, early clinical applications resulted in a negative shift of opinion ...
Carl R Merril, Dean Scholl, Sankar Adhya
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Phage Therapy: Delivering on the Promise
Therapeutic Delivery, 2011Bacteriophages are viruses that infect and, in many cases, destroy their bacterial targets. Within a few years of their initial discovery they were being investigated as therapeutic agents for infectious disease, an approach known as phage therapy. However, the nature of these exquisitely specific agents was not understood and much early use was both ...
D R, Harper, J, Anderson, M C, Enright
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Phage therapy: From biological mechanisms to future directions
Cell, 2023Vivek Mutalik +2 more
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Phage therapy pharmacology phage cocktails.
Advances in applied microbiology, 2016Phage therapy is the clinical or veterinary application of bacterial viruses (bacteriophages) as antibacterial "drugs." More generally, phages can be used as biocontrol agents against plant as well as foodborne pathogens. In this chapter, we consider the therapeutic use of phage cocktails, which is the combining of two or more phage types to produce ...
Benjamin K, Chan, Stephen T, Abedon
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History of Phage Research and Phage Therapy
2014Bacteriophages are widely distributed and exhibit dramatic manifestations both in liquid cultures and on solid media. Felix d’Herelle’s research had two important directions, focusing on (i) the therapeutic use of the phage in infectious diseases and (ii) the biological nature of the bacteriophage itself. From his first studies of clinical samples from
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The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies
Viruses, 2021Dan Liu, Gina Suh
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