Results 41 to 50 of about 114,190 (344)

Animal Models of Phage Therapy [PDF]

Frontiers in Microbiology, 2021
Amidst the rising tide of antibiotic resistance, phage therapy holds promise as an alternative to antibiotics. Most well-designed studies on phage therapy exist in animal models. In order to progress to human clinical trials, it is important to understand what these models have accomplished and determine how to improve upon them.
Samuel Penziner, Robert T. Schooley, David T. Pride, David T. Pride   +3 more
openaire   +3 more sources

Encapsulation of E. coli phage ZCEC5 in chitosan–alginate beads as a delivery system in phage therapy

AMB Express, 2019
Bacteriophages can be used successfully to treat pathogenic bacteria in the food chain including zoonotic pathogens that colonize the intestines of farm animals.
Abdallah S. Abdelsattar, Fatma Abdelrahman, Alyaa Dawoud, Ian F. Connerton, Ayman El-Shibiny   +4 more
doaj   +1 more source

The bacteriophage decides own tracks: When they are with or against the bacteria

Current Research in Microbial Sciences, 2021
Bacteriophages, bacteria-infecting viruses, are considered by many researchers a promising solution for antimicrobial resistance. On the other hand, some phages have shown contribution to bacterial resistance phenomenon by transducing antimicrobial ...
Salsabil Makky, Alyaa Dawoud, Anan Safwat, Abdallah S. Abdelsattar, Nouran Rezk, Ayman El-Shibiny   +5 more
doaj   +1 more source

Therapeutic antibodies: current state and future trends--is a paradigm change coming soon? [PDF]

, 2008
Antibody-based therapeutics currently enjoy unprecedented success, growth in research and revenues, and recognition of their potential. It appears that the promise of the "magic bullet" has largely been realized.
Dimitrov, Dimiter S, Marks, James D
core   +1 more source

Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii [PDF]

, 2020
The multi-drug resistance of the opportunistic pathogen Acinetobacter baumannii is of growing concern, with many clinical isolates proving to be resistant to last resort as well as front line antibiotic treatments.
Christie, Gabrielle S., Dowson, Christopher G., Leungtongkam, Udomluk, Millard, Andrew D., Moat, John, Sagona, Antonia P., Sitthisak, Sutthirat, Smith, Sophie, Styles, Kathryn, Thummeepak, Rapee, Wellington, Elizabeth M. H.   +10 more
core   +1 more source

Isolation, Characterization, and Genomic Analysis of Three Novel E. coli Bacteriophages That Effectively Infect E. coli O18

Microorganisms, 2022
Escherichia coli (E. coli) is one of the most common pathogenic bacteria worldwide. Avian pathogenic E. coli (APEC) causes severe systemic disease in poultry (Colibacillosis), and accordingly, has an extreme risk to the poultry industry and public health
Fatma Abdelrahman, Nouran Rezk, Mohamed S. Fayez, Mohamed Abdelmoteleb, Reham Atteya, Mohamed Elhadidy, Ayman El-Shibiny   +6 more
doaj   +1 more source

Bacterial competition and quorum-sensing signalling shapes the eco-evolutionary outcomes of model in vitro phage therapy [PDF]

, 2016
The rapid rise of antibiotic resistance has renewed interest in phage therapy - the use of bacteria-specific viruses (phages) to treat bacterial infections.
Abedon, Alisky, Andersen, Asfahl, Betts, Betts, Buckling, Debarbieux, Diggle, Essoh, Expert round table on, acceptance and therapy re-implementation of bacteriophage, Fletcher, Folkesson, Friman, Friman, Friman, Frydenlund Michelsen, Ghoul, Glessner, Hall, Harcombe, Harper, Harrison, Harrison, Hoffman, Housby, Hoyland-Kroghsbo, Inglis, Jelsbak, Jorth, Kassen, Korgaonkar, Kutateladze, Lenski, Levin, Levy, Lopez-Pascua, Marvig, Merabishvili, Merabishvili, Michelsen, Miller, Peters, R Core Team, Rose, Rossolini, Ryan, Seed, Smith, Strateva, Taj, Tan, Turner, Vasse, Yoshida   +54 more
core   +2 more sources

Transmission of viruses via our microbiomes. [PDF]

, 2016
BackgroundBacteria inhabiting the human body have important roles in a number of physiological processes and are known to be shared amongst genetically-related individuals.
Abeles, Shira R, Chan, Ivan C, Gao, Jonathan, Ghose, Chandrabali, Jones, Marcus B, Ly, Melissa, Pride, David T, Santiago-Rodriguez, Tasha M   +7 more
core   +1 more source

The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]

, 2014
Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core   +2 more sources

Making serine integrases work for us [PDF]

, 2017
DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core   +1 more source